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Titolo:
Cost effectiveness analysis of a population based screening programme for asymptomatic Chlamydia trachomatis infections in women by means of home obtained urine specimens
Autore:
van Valkengoed, IGM; Postma, MJ; Morre, SA; van den Brule, AJC; Meijer, CJLM; Bouter, LM; Boeke, AJP;
Indirizzi:
Free Univ Amsterdam, Inst Res Extramural Med, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 BT terdam, Netherlands Univ Groningen, Inst Drug Explorat, Groningen, Netherlands Univ GroningenGroningen Netherlands g Explorat, Groningen, Netherlands Free Univ Amsterdam Hosp, Dept Pathol, Sect Mol Pathol, Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands , Amsterdam, Netherlands
Titolo Testata:
SEXUALLY TRANSMITTED INFECTIONS
fascicolo: 4, volume: 77, anno: 2001,
pagine: 276 - 282
SICI:
1368-4973(200108)77:4<276:CEAOAP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PELVIC INFLAMMATORY DISEASE; ECONOMIC-EVALUATION; GENERAL-PRACTICE; CRITERIA;
Keywords:
cost effectiveness analysis; Chlamydia trachomatis; screening;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Boeke, AJP Free Univ Amsterdam, Inst Res Extramural Med, Van Der Voechorststr 7, NL-1081 BT Amsterdam, Netherlands Free Univ Amsterdam Van Der Voechorststr 7 Amsterdam Netherlands NL-1081 BT
Citazione:
I.G.M. van Valkengoed et al., "Cost effectiveness analysis of a population based screening programme for asymptomatic Chlamydia trachomatis infections in women by means of home obtained urine specimens", SEX TRANS I, 77(4), 2001, pp. 276-282

Abstract

Objectives: To evaluate the cost effectiveness of a systematic screening programme for asymptomatic Chlamydia, trachomatis infections in a female inner city population. To determine the sensitivity of the cost effectiveness analysis to variation in the probability of developing sequelae. Methods: A decision tree was constructed to evaluate health effects of theprogramme, such as averted sequelae, of chlamydial infection. Cost effectiveness from a societal perspective was estimated for screening by means of a ligase chain reaction on mailed, home obtained urine specimens, in a population with a C trachomatis test prevalence of 2.9%. An extensive sensitivity analysis was performed for the probability of sequelae, the percentage of preventable pelvic inflammatory disease (PID), and the discount rate. Results: The estimated net cost of curing one woman, aged 15-40 years, of a C trachomatis infection is US$1210. To prevent one major outcome (PID, tubal factor infertility ectopic pregnancy, chronic pelvic pain, or neonatal pneumonia), 479 women would have to be screened. The net cost of preventingone major outcome is $15 800. Changing the probability of PID after chlamydial infection from 5% to 25% decreases the net cost per major outcome averted from $28 300 to $6380, a reduction of 78%. Results were less sensitive to variations in estimates for other sequelae. The breakeven prevalence of the programme ranges from 6.4% for the scenario with all probabilities for complications set at the maximum value to a prevalence of 100% for probabilities set at the minimum value. Conclusions: Systematic screening of all women aged 15-40 years for asymptomatic C trachomatis infections is not cost effective. Although the resultsof the analyses are sensitive to variation in the assumptions, the costs exceed the benefits, even in the most optimistic scenario.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:52:42