Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Uninephrectomy increases kidney beta 2-microglobulin: Can it play a role in the progression of kidney damage?
Autore:
Bianchi, C; Donadio, C; Tramonti, G; Consani, C; Lorusso, P; Bonino, C; Lunghi, F;
Indirizzi:
Univ Pisa, Dept Internal Med, UO Nefrol Univ, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 al Med, UO Nefrol Univ, I-56100 Pisa, Italy
Titolo Testata:
RENAL FAILURE
fascicolo: 3-4, volume: 23, anno: 2001,
pagine: 507 - 516
SICI:
0886-022X(2001)23:3-4<507:UIKB2C>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; TRYPSIN-INHIBITOR TATI; CHRONIC RENAL-FAILURE; BENCE-JONES PROTEINS; SERUM LEVEL; CYSTATIN-C; BETA2-MICROGLOBULIN; BETA(2)-MICROGLOBULIN; ALPHA-1-MICROGLOBULIN; INSUFFICIENCY;
Keywords:
uninephrectomy; beta 2-microglobulin; hypermetabolism; progression of kidney damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bianchi, C Osped S Chaira, UO Nefrol Univ, Dipartimento Med Interna, I-56100 Pisa, Italy Osped S Chaira Pisa Italy I-56100 nterna, I-56100 Pisa, Italy
Citazione:
C. Bianchi et al., "Uninephrectomy increases kidney beta 2-microglobulin: Can it play a role in the progression of kidney damage?", RENAL FAIL, 23(3-4), 2001, pp. 507-516

Abstract

beta2-microglobulin (beta 2M) is highly accumulated by the kidneys of normal rats. The aim of this study was to verify if uninephrectomy can modify the renal uptake of labeled beta 2M. For this purpose the radioactivity of plasma and those of the remaining kidney, liver and urine have been measuredin uninephrectomized rats (NX} and in controls (C) at different times after the injection as i.v. bolus of I-131-beta 2M. The experiments were performed in 114 Sprague-Dawley male rats. Fifty seven animals underwent right nephrEctomy, the other animals being the C. NX and their C were divided in 3 groups, studied 2, 4 and 6 weeks after nephrectomy, respectively. Part of the animals were sacrificed 12 min after the injection of labeled beta 2M (peak-time, i.e. time of highest kidney accumulation of I-131-beta 2M in the normal rat} and part 10 min later. The results demonstrate that:- uninephrectomy increases plasma retention of I-131-beta 2M- kidney uptake (total and per gram) is always higher in NX- liver uptake (much lower than that of kidney) is not influenced by uninephrectomy- urine excretion of radioactivity is minimal in both NX and C. The behavior of beta 2M is similar to that we previously observed with alpha1-microglobulin and lysozyme. The higher kidney content of some low mw proteins after uninephrectomy could play a role in the progressive reduction of renal function determined by the reduction of renal mass.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:20:52