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Titolo:
Relationship between renal function and blood level of chromogranin A
Autore:
Tramonti, G; Ferdeghini, M; Annichiarico, C; Norpoth, M; Donadio, C; Bianchi, R; Bianchi, C;
Indirizzi:
Univ Pisa, Dipartimento Med Interna, Sez Nefrol, Pisa, Italy Univ Pisa Pisa Italy Dipartimento Med Interna, Sez Nefrol, Pisa, Italy Univ Pisa, Dipartimento Oncol, Sez Med Nucl, Pisa, Italy Univ Pisa Pisa Italy isa, Dipartimento Oncol, Sez Med Nucl, Pisa, Italy
Titolo Testata:
RENAL FAILURE
fascicolo: 3-4, volume: 23, anno: 2001,
pagine: 449 - 457
SICI:
0886-022X(2001)23:3-4<449:RBRFAB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; NEURON-SPECIFIC ENOLASE; TRYPSIN-INHIBITOR TATI; SERUM CYSTATIN-C; TUMOR-MARKERS; HEMODIALYSIS-PATIENTS; DISEASE; BETA-2-MICROGLOBULIN; INSUFFICIENCY; CREATININE;
Keywords:
beta(2) microglobulin; chromogranin A; glomerular filtration rate; tumor associated with trypsin inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Tramonti, G UO Nefrol Univ, Dipartimento Med Interna, Via Roma 67, I-56100Pisa, Italy UO Nefrol Univ Via Roma 67 Pisa Italy I-56100 100 Pisa, Italy
Citazione:
G. Tramonti et al., "Relationship between renal function and blood level of chromogranin A", RENAL FAIL, 23(3-4), 2001, pp. 449-457

Abstract

Chromogranin A (CGA) is a low MW (49,000) acidic hydrophilic protein. It is synthesized in the chromaffm granules of the neuroendocrine cells, and has been found circulating in the blood of healthy subjects. The aim of this study was to assess the relationship between serum levels of CGA and renal function. One hundred two renal patients (45 M and 57 F; age 14-76 years, mean 52) participated in the study. Glomerular filtration rate (GFR) was measured by the bladder cumulative method, using Tc-99m-DTPA as a tracer. Blood CGA was determined by RIA. Plasma creatinine, beta (2)microglobulin (beta(2)m) and tumor associated trypsin inhibitor (TATI) were also determined. The reduction in renal function was associated with an increase in all of the above studied parameters. In patients with advanced renal failure (GFR <20 mL/min) CGA levels increased by 22-fold as compared to the patients with normal renal function (GFR > 100 mL/min). The other studied parameters were also increased but to a lesser degree, e.g., TATI 14-, beta (2)m 8- and creatinine 5-fold. The results of this study demonstrate that renal handling of the CGA is similar to other low MW proteins, and it accumulates in theblood in renal failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:34:34