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Titolo:
Relevance of aldo-keto reductase family members to the pathobiology of diabetic nephropathy and renal development
Autore:
Wallner, EI; Wada, J; Tramonti, G; Lin, S; Srivastava, SK; Kanwar, YS;
Indirizzi:
Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Pathol, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Dept Med, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 d, Dept Med, Chicago, IL 60611 USA Okayama Univ, Sch Med, Dept Internal Med 3, Okayama 700, Japan Okayama Univ Okayama Japan 700 , Dept Internal Med 3, Okayama 700, Japan Univ Texas, Med Branch, Dept Human Biol Chem & Genet, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 l Chem & Genet, Galveston, TX 77550 USA
Titolo Testata:
RENAL FAILURE
fascicolo: 3-4, volume: 23, anno: 2001,
pagine: 311 - 320
SICI:
0886-022X(2001)23:3-4<311:ROARFM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SITE-DIRECTED MUTAGENESIS; MESSENGER-RNA EXPRESSION; ALDEHYDE REDUCTASE; GENE-EXPRESSION; HUMAN-PLACENTA; IDENTIFICATION; METHYLGLYOXAL; COMPLICATIONS; PURIFICATION; SUPERFAMILY;
Keywords:
diabetic nephropathy; aldo-keto reductase; metanephric development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wallner, EI Northwestern Univ, Sch Med, Dept Pathol, 303 E Chicago Ave,Ward 6-076, Chicago, IL 60611 USA Northwestern Univ 303 E Chicago Ave,Ward 6-076 Chicago IL USA 60611
Citazione:
E.I. Wallner et al., "Relevance of aldo-keto reductase family members to the pathobiology of diabetic nephropathy and renal development", RENAL FAIL, 23(3-4), 2001, pp. 311-320

Abstract

Aldo-keto reductases (AKRs) are a family of monomeric oxido-reductases with molecular weight ranging from 35-40 kDa and currently includes upwards of60 members. They are expressed in a wide variety of tissues, where they catalyze the NADPH-dependent reduction of various aliphatic and aromatic aldehydes and ketones. The functions of most of the family members are not welldefined. But two members, aldehyde reductase (AKR1A) and aldose reductase (AKR1B), have been extensively studied. The latter has received the most attention since being relevant to the complications of diabetes mellitus: It is upregulated during hyperglycemia, and at the same time there is an increased activity of the sorbitol pathway aAlthough, it has no homology with other AKR members, it binds to NADPH with high affinity and is up-regulated in streptozotocin-induced diabetes in mice. It is also developmentally regulated and seems to selectively modulate renal tubulogenesis during embryoniclife.nd non-enzymatic glycation of proteins with ensuing damage in varioustissues. It is developmentally regulated in the ocular lens, and is believed to modulate lens fiber morphogenesis during fetal life. Unlike the otherAKR family members that are ubiquitously expressed, recently a renal-specific oxio-reductase has been described that. is expressed exclusively in theproximal tubules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:50:14