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Titolo:
Effects of sleep on endotoxin-induced host responses in healthy men
Autore:
Haack, M; Schuld, A; Kraus, T; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
PSYCHOSOMATIC MEDICINE
fascicolo: 4, volume: 63, anno: 2001,
pagine: 568 - 578
SICI:
0033-3174(200107/08)63:4<568:EOSOEH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; SLOW-WAVE SLEEP; DEPRIVATION; LIPOPOLYSACCHARIDE; IMMUNE; HUMANS; MICE; SECRETION; CYTOKINES; RAT;
Keywords:
sleep; slow wave sleep; endotoxin; infection; cytokines; cortisol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, D-80804 Munich, Germany Max PlanckInst Psychiat Munich Germany D-80804 h, Germany
Citazione:
M. Haack et al., "Effects of sleep on endotoxin-induced host responses in healthy men", PSYCHOS MED, 63(4), 2001, pp. 568-578

Abstract

Objective: To examine whether increased sleep during viral or bacterial infections supports host defense mechanisms. Methods: To test this assumptionin humans, healthy male subjects were assigned either to sleep from 2300 to 0700 hours (n = 10) or to stay awake through the night (n = 10). In the sleeping subjects Salmonella abortus equi endotoxin (0.4 ng/kg) or placebo were intravenously injected in balanced order during the first SWS episode. The age-matched, sleep-deprived subjects were injected at the same time point. Results: As expected, endotoxin significantly increased rectal temperature, the plasma levels of cortisol, tumor necrosis factor-alpha (TNF-alpha), the soluble TNF receptors p55 and p75, Interleukin (IL)-6, the IL-1 receptor antagonist (RA), leukocyte, and granulocyte counts in both sleeping andsleep-deprived subjects, whereas lymphocyte and monocyte counts were transiently reduced. Time courses of endotoxin-induced host responses did not differ between the sleep and sleep deprivation groups. Endotoxin did not affect the amount of nocturnal wakefulness, nonrapid-eve-movement (NREM) sleep,or rapid-eye-movement (REM) sleep across the total night compared with placebo, but significantly increased electroencephalogram-arousals (EEG-arousals) in stage 2 and decreased arousals in SWS. In addition, the amount of SWS, spectral EEG-delta and -theta power was increased at the beginning and at the end of the sleep period, respectively, when the degree of immune activation was relatively low. Conclusion: The present results support the notion that short-term sleep deprivation is unlikely to harm the immune system as far as unspecific acute responses are concerned. The effects of endotoxin on sleep in this case support prior observations that in humans, enhancedSWS and intensified NREM sleep occur when host defense activation is subtle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:47:08