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Titolo:
ACUTE NICOTINE INTERACTIONS WITH NICOTINIC AND MUSCARINIC ANTAGONISTS- WORKING AND REFERENCE MEMORY EFFECTS IN THE 16-ARM RADIAL MAZE
Autore:
LEVIN ED; KAPLAN S; BOARDMAN A;
Indirizzi:
DUKE UNIV,MED CTR,DEPT PSYCHIAT,NEUROBEHAV RES LAB,BOX 3412 DURHAM NC27710 DUKE UNIV,MED CTR,DEPT PHARMACOL DURHAM NC 27710
Titolo Testata:
Behavioural pharmacology
fascicolo: 2-3, volume: 8, anno: 1997,
pagine: 236 - 242
SICI:
0955-8810(1997)8:2-3<236:ANIWNA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-TERM-MEMORY; ACUTE TOLERANCE; ARM MAZE; ALZHEIMERS-DISEASE; MECAMYLAMINE; RATS; PERFORMANCE; RECEPTORS; BLOCKADE; CELLS;
Keywords:
MECAMYLAMINE; MEMORY; NICOTINE; RADIAL-ARM MAZE; RAT; REFERENCE MEMORY; SCOPOLAMINE; WORKING MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
E.D. Levin et al., "ACUTE NICOTINE INTERACTIONS WITH NICOTINIC AND MUSCARINIC ANTAGONISTS- WORKING AND REFERENCE MEMORY EFFECTS IN THE 16-ARM RADIAL MAZE", Behavioural pharmacology, 8(2-3), 1997, pp. 236-242

Abstract

In the 8-arm radial maze and other tests, acute nicotine administration has been found to improve memory performance significantly, whereasacute administration of the nicotinic antagonist mecamylamine has been found to impair memory performance. However, questions remain concerning the behavioral and pharmacological nature of acute nicotine effects on memory. In the current studies, we examined acute nicotine effects on working and reference memory in a 16-arm radial maze. In the first study, nicotine caused a significant improvement in working memory but not in reference memory. The muscarinic antagonist scopolamine caused significant deficits in working memory but not in reference memory. Nicotine did not significantly attenuate the scopolamine-induced deficit. In the second study, with rats trained to near-perfect performance, a low dose of mecamylamine (1.25 mg/kg) caused a significant working memory impairment in the 16-arm maze. This deficit was significantly attenuated by concurrent acute administration of nicotine. These studies show that acute nicotine, like chronic nicotine, preferentially improves working compared with reference memory in the radial-arm maze. Mecamylamine can impair working memory performance in the 16-arm mazeat low doses which are less likely to have effects at N-methyl-D-aspartate receptors. Nicotine can selectively reverse mecamylamine-induceddeficits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:58:38