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Titolo:
SALBUTAMOL OVERCOMES THE EFFECT OF THE NORADRENERGIC NEUROTOXIN DSP-4ON MEMORY FUNCTION IN THE DAY-OLD CHICK
Autore:
CROWE SF; SHAW S;
Indirizzi:
LA TROBE UNIV,SCH PSYCHOL BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
Behavioural pharmacology
fascicolo: 2-3, volume: 8, anno: 1997,
pagine: 216 - 222
SICI:
0955-8810(1997)8:2-3<216:SOTEOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PASSIVE-AVOIDANCE TASK; NORADRENALINE; CONSOLIDATION; ADRENOCEPTOR; PERFORMANCE; INVOLVEMENT; ANTAGONIST; AMNESIA; STORAGE; RATS;
Keywords:
ADRENERGIC AGENTS; CONSOLIDATION; DAY-OLD CHICKS; DSP-4; LONG-TERM MEMORY; NORADRENALINE; SALBUTAMOL; TRAINING STIMULUS INTENSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S.F. Crowe e S. Shaw, "SALBUTAMOL OVERCOMES THE EFFECT OF THE NORADRENERGIC NEUROTOXIN DSP-4ON MEMORY FUNCTION IN THE DAY-OLD CHICK", Behavioural pharmacology, 8(2-3), 1997, pp. 216-222

Abstract

These experiments investigated the effect of the relatively selectivenoradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine(DSP-4) on memory formation in day-old chicks trained on a discriminated passive avoidance task. A time course study showed that DSP-4 treatment resulted in amnesia as early as 20 min post-learning. In a second study, a series of alpha- and beta-adrenergic agonists (noradrenaline; the alpha 1 agonist phenylephrine; the beta 1 agonist dobutamine; and the beta 2 agonist salbutamol) were applied immediately after the training trial. Both noradrenaline and salbutamol were effective in ameliorating the memory deficits caused by DSP-4 treatment, and in consolidating weakly reinforced training. These studies support the notion that noradrenaline subserves a vital role in the consolidation of memory in the chick, and that the beta 2 receptor subtypes are principally involved in the intermediate phase of memory formation.

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Documento generato il 03/04/20 alle ore 13:59:43