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Titolo:
Cognitive decline in schizophrenics with Alzheimer's disease: A mini-review of neuropsychological and neuropathological studies
Autore:
Niizato, K; Genda, K; Nakamura, R; Iritani, S; Ikeda, K;
Indirizzi:
Tokyo Metropolitan Matsuzawa Hosp, Dept Psychiat, Setagaya Ku, Tokyo 1560057, Japan Tokyo Metropolitan Matsuzawa Hosp Tokyo Japan 1560057 kyo 1560057, Japan Tokyo Inst Psychiat, Dept Neuropathol, Tokyo, Japan Tokyo Inst Psychiat Tokyo Japan sychiat, Dept Neuropathol, Tokyo, Japan
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 25, anno: 2001,
pagine: 1359 - 1366
SICI:
0278-5846(200110)25:7<1359:CDISWA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN EPSILON-4 ALLELE; ELDERLY SCHIZOPHRENICS; BRAIN PATHOLOGY; E POLYMORPHISM; LONG-TERM; ASSOCIATION; FREQUENCY; DEMENTIA; NEUROLEPTICS; INHIBITION;
Keywords:
Alzheimer's disease; antipsychotic drug; apolipoprotein E; cognitive impairment; schizophrenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Niizato, K Tokyo Metropolitan Matsuzawa Hosp, Dept Psychiat, Setagaya Ku, 2-1-1 Kamikitazawa, Tokyo 1560057, Japan Tokyo Metropolitan Matsuzawa Hosp 2-1-1 Kamikitazawa Tokyo Japan 1560057
Citazione:
K. Niizato et al., "Cognitive decline in schizophrenics with Alzheimer's disease: A mini-review of neuropsychological and neuropathological studies", PROG NEUR-P, 25(7), 2001, pp. 1359-1366

Abstract

1. Cognitive decline in elderly schizophrenic patients is an important clinical symptom, but it is often difficult to analyze in detail due to the patient's original residual psychotic symptoms.2. In this article, the authors provide neuropsychological and neuropathological research information about cognitive decline in elderly schizophrenic patients, especially with reference to Alzheimer's disease (AD). Neuropsychological and neuropathological reports about cognitive impairments are reviewed. The effect of long-term antipsychotic medication upon cognitive function is also discussed.3. As a result, it is apparent that elderly schizophrenic patients often show cognitive impairments, however, such impairments do not have the characteristics of progressive degenerative illnesses such as AD, and the speed of their progress is very slow. Neuropathological studies have shown that ADbrain pathology appears no more frequently among schizophrenic patients than in the normal population.4. Since making a diagnosis. of AD means that the progressive deterioration not only of cognitive function, but also of physical ability, parallelingthe degeneration of the central nervous system, can be expected within a few years and appropriate care will be required. One should be very cautiousin adding a diagnosis of AD to elderly schizophrenic patients with cognitive impairments.

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Documento generato il 05/04/20 alle ore 18:10:29