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Titolo:
Activity of body energy regulatory pathways in inflammation-induced anorexia
Autore:
Lennie, TA; Mortman, MD; Seeley, RJ;
Indirizzi:
Ohio State Univ, Coll Nursing, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 oll Nursing, Columbus, OH 43210 USA Univ Cincinnati, Dept Psychiat, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 sychiat, Cincinnati, OH 45267 USA
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 4, volume: 73, anno: 2001,
pagine: 517 - 523
SICI:
0031-9384(200107)73:4<517:AOBERP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROOPIOMELANOCORTIN MESSENGER-RNA; TUMOR-NECROSIS-FACTOR; FOOD-INTAKE; GENE-EXPRESSION; ARCUATE NUCLEUS; PLASMA LEPTIN; INSULIN; INCREASES; WEIGHT; RATS;
Keywords:
leptin; POMC; inflammation-induced anorexia; body weight loss; IL-1 beta; IL-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Lennie, TA Ohio State Univ, Coll Nursing, 1585 Neil Ave, Columbus, OH 43210 USA Ohio State Univ 1585 Neil Ave Columbus OH USA 43210 H 43210 USA
Citazione:
T.A. Lennie et al., "Activity of body energy regulatory pathways in inflammation-induced anorexia", PHYSL BEHAV, 73(4), 2001, pp. 517-523

Abstract

Previous research has shown that reductions in body weight prior to induction of acute inflammation can attenuate inflammation- induced anorexia in male rats. In the current study, potential mechanisms responsible for this observation were examined. Specifically, the effect of a 12% prior reductionin body weight on serum leptin, insulin, and corticosterone; levels of interleukin- I (IL-1), interleukin-6 (IL-6) in the scrum, liver, and spleen; neuropeptide Y (NPY) and POW mRNA levels in the arcuate nucleus (ARC) of thehypothalamus were examined 8 h after induction of acute inflammation. Ratswith prior weight reduction had significantly lower serum leptin levels and gene expression of POW in the ARC than normal-weight rats. In contrast, prior weight reduction altered neither NPY mRNA in the ARC, nor IL-1 alpha, IL-1 beta, and IL-6 levels in the serum, liver, and spleen. These results suggest that the attenuation of inflammation-induced anorexia by prior weight reduction is not due to altered cytokine activity, but rather to changes in energy regulatory systems that moderate the anorexic actions of IL-1 beta and IL-6. One potential change may be reduced activity of the CNS melanocortin system induced by decreased circulating leptin. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 28/11/20 alle ore 18:16:08