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Titolo:
Monitoring of deep brain temperature in infants using multi-frequency microwave radiometry and thermal modelling
Autore:
Hand, JW; Van Leeuwen, GMJ; Mizushina, S; Van de Kamer, JB; Maruyama, K; Sugiura, T; Azzopardi, DV; Edwards, AD;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Imaging, RadiolSci Unit, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland TAO Hamamatsu Lifeline Res Ctr, Shizuoka 4328061, Japan TAO Hamamatsu Lifeline Res Ctr Shizuoka Japan 4328061 oka 4328061, Japan Univ Utrecht, Med Ctr, Dept Radiotherapy, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Shizuoka Univ, Elect Res Inst, Hamamatsu, Shizuoka 4328011, Japan ShizuokaUniv Hamamatsu Shizuoka Japan 4328011 u, Shizuoka 4328011, Japan Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Paediat, LondonW12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland
Titolo Testata:
PHYSICS IN MEDICINE AND BIOLOGY
fascicolo: 7, volume: 46, anno: 2001,
pagine: 1885 - 1903
SICI:
0031-9155(200107)46:7<1885:MODBTI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIELECTRIC-PROPERTIES; IN-VIVO; BIOLOGICAL TISSUES; DISTRIBUTIONS; SPECTROSCOPY; HYPERTHERMIA; THERMOGRAPHY; THERMOMETRY; GHZ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Hand, JW Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Imaging, RadiolSci Unit, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN
Citazione:
J.W. Hand et al., "Monitoring of deep brain temperature in infants using multi-frequency microwave radiometry and thermal modelling", PHYS MED BI, 46(7), 2001, pp. 1885-1903

Abstract

In this study we present a design for a multi-frequency microwave radiometer aimed at prolonged monitoring of deep brain temperature in newborn infants and suitable for use during hypothermic neural rescue therapy. We identify appropriate hardware to measure brightness temperature and evaluate the accuracy of the measurements. We describe a method to estimate the tissue temperature distribution from measured brightness temperatures which uses the results of numerical simulations of the tissue temperature as well as thepropagation of the microwaves in a realistic detailed three-dimensional infant head model. The temperature retrieval method is then used to evaluate how the statistical fluctuations in the measured brightness temperatures limit the confidence interval for the estimated temperature: for an 18 degreesC temperature differential between cooled surface and deep brain we found a standard error in the estimated central brain temperature of 0.75 degreesC. Evaluation of the systematic errors arising from inaccuracies in model parameters showed that realistic deviations in tissue parameters have littleimpact compared to uncertainty in the thickness of the bolus between the receiving antenna and the infant's head or in the skull thickness. This highlights the need to pay particular attention to these latter parameters in future practical implementation of the technique.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:05:54