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Titolo:
MERCURIC-CHLORIDE TOXICITY IN RAT-LIVER MITOCHONDRIA AND ISOLATED HEPATOCYTES
Autore:
PALMEIRA CM; MADEIRA VMC;
Indirizzi:
UNIV COIMBRA,DEPT ZOOL P-3049 COIMBRA PORTUGAL UNIV COIMBRA,DEPT BIOCHEM P-3049 COIMBRA PORTUGAL
Titolo Testata:
Environmental toxicology and pharmacology
fascicolo: 3, volume: 3, anno: 1997,
pagine: 229 - 235
SICI:
1382-6689(1997)3:3<229:MTIRMA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION; BIOENERGETICS; GLUTATHIONE; CADMIUM; INJURY;
Keywords:
MERCURIC CHLORIDE TOXICITY; LIVER; MITOCHONDRIA; HEPATOCYTES; ATP; GLUTATHIONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Palmeira e V.M.C. Madeira, "MERCURIC-CHLORIDE TOXICITY IN RAT-LIVER MITOCHONDRIA AND ISOLATED HEPATOCYTES", Environmental toxicology and pharmacology, 3(3), 1997, pp. 229-235

Abstract

The effects of mercuric chloride on isolated rat liver mitochondria and freshly isolated rat hepatocytes were investigated. Mercuric chloride (in the mu M range) depresses state 3 respiration, suggesting a strong effect at the level of the phosphorylation system. It also stimulates state 4 respiration and decreases mitochondrial membrane potential, suggesting an uncoupling action. In isolated hepatocytes, mercuric chloride causes a dose- and time-dependent cell death, accompanied by depletion of intracellular glutathione. Furthermore, mercuric chloride decreases intracellular ATP ana ADP levels simultaneously with increasing AMP concentration, indicating fast hydrolysis of ATP without adequate rephosphorylation. From this study we can conclude that the bioenergetic lesion promoted by mercuric chloride seems to be sufficient to explain lethal hepatocyte injury. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:13:11