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Titolo:
Early proactive management of vestibular schwannomas in neurofibromatosis type 2
Autore:
Brackmann, DE; Fayad, JN; Slattery, WH; Friedman, RA; Day, JD; Hitselberger, WE; Owens, RM;
Indirizzi:
House Ear Res Inst, Dept Clin Studies, Los Angeles, CA 90057 USA House EarRes Inst Los Angeles CA USA 90057 es, Los Angeles, CA 90057 USA House Ear Clin, Los Angeles, CA USA House Ear Clin Los Angeles CA USAHouse Ear Clin, Los Angeles, CA USA
Titolo Testata:
NEUROSURGERY
fascicolo: 2, volume: 49, anno: 2001,
pagine: 274 - 280
SICI:
0148-396X(200108)49:2<274:EPMOVS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC NEUROMA SURGERY; HEARING PRESERVATION; TUMORS; GENE;
Keywords:
acoustic tumor; hearing preservation; neurofibromatosis type 2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Brackmann, DE House Ear Res Inst, Dept Clin Studies, 2100 W 3rd St,5th Floor, Los Angeles, CA 90057 USA House Ear Res Inst 2100 W 3rd St,5th Floor Los Angeles CA USA 90057
Citazione:
D.E. Brackmann et al., "Early proactive management of vestibular schwannomas in neurofibromatosis type 2", NEUROSURGER, 49(2), 2001, pp. 274-280

Abstract

OBJECTIVE: The treatment of patients with neurofibromatosis Type 2 has always been challenging for neurosurgeons and neurotologists. Guidelines for appropriate management of this devastating disease are controversial. METHODS: A retrospective study of 28 patients with neurofibromatosis Type 2 who underwent 40 middle fossa craniotomies for excision of their acoustictumors is reported. Eleven patients underwent bilateral procedures. The study focused on hearing preservation and facial nerve results for this groupof patients. The 16 male patients and 12 female patients ranged in age (atthe time of surgery) from 10 to 70 years, with a mean age of 22.6 years. The mean tumor size was 1.1 cm (range, 0.5-3.2 cm), and the majority of tumors were less than 1.5 cm. RESULTS: Measurable hearing was preserved in 28 ears (70%), with 42.5% being within 15 dB pure-tone average and 15% speech discrimination score of preoperative levels. In 55% of cases there was no change in the hearing class, as defined by the American Academy of Otolaryngology-Head and Neck Surgery. Of the 11 patients who underwent bilateral operations, 9 (82%) retained some hearing bilaterally. After 1-year follow-up periods (mean, 12.8 mo), 87.5% of patients exhibited normal facial nerve function (House-Brackmann Grade I). CONCLUSION: Early surgical intervention to treat acoustic tumors among patients with neurofibromatosis Type 2 is a feasible treatment strategy, with high rates of hearing and facial nerve function preservation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:05:17