Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake-sleep states
Autore:
Sakai, K; Crochet, S;
Indirizzi:
Univ Lyon 1, Dept Expt Med, INSERM, U480, F-69373 Lyon 08, France Univ Lyon 1 Lyon France 08 pt Med, INSERM, U480, F-69373 Lyon 08, France
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 104, anno: 2001,
pagine: 1141 - 1155
SICI:
0306-4522(2001)104:4<1141:DOPSDR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; FREELY MOVING CATS; LOWER BRAIN-STEM; PARADOXICAL SLEEP; UNIT-ACTIVITY; WAKING CYCLE; PGO WAVES; PARA-CHLOROPHENYLALANINE; TEGMENTAL NEURONS; LOCUS-COERULEUS;
Keywords:
dorsal raphe nucleus; serotonin; single unit activity; sleep wake states; microdialysis; cat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Sakai, K Univ Lyon 1, Dept Expt Med, INSERM, U480, 8 Ave Rockerfeller, F-69373 Lyon08, France Univ Lyon 1 8 Ave Rockerfeller Lyon France 08 373 Lyon08, France
Citazione:
K. Sakai e S. Crochet, "Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake-sleep states", NEUROSCIENC, 104(4), 2001, pp. 1141-1155

Abstract

Using extracellular single unit recording, either alone or in combination with microdialysis application of drugs, we examined the characteristics ofpresumed serotonergic dorsal raphe neurons during wake-sleep states in thefreely moving cat. Recordings were made from a total of 272 neurons in thedorsal raphe nucleus. Of these. 240 (88%) were classified as serotonergic on the basis of their typical long duration action potential. slow discharge activity, and reduced spontaneous discharge rate during paradoxical sleepcompared to during slow-wave sleep. An inhibitory response to serotonergicagonists and a slow conduction velocity were seen in all neurons of this type tested or identified by stimulation of the main ascending serotonergic pathway, These presumed serotonergic dorsal raphe neurons could be subdivided into two typical previously identified groups (types I-A and I-B) and four atypical new groups (types I-C, II-A. II-B, and II-C) according to differences in firing patterns during wake sleep states. The typical neurons were evenly distributed in the dorsal raphe nucleus and their activity was related to the level of behavioral arousal. since they discharged regularly ata high rate during waking and at progressively slower rates during slow-wave sleep, and ceased firing either during slow-wave sleep with ponto-geniculo-occipital waves and paradoxical sleep (type I-A) or only during paradoxical sleep (type I-B). In contrast, the atypical subgroups were unevenly distributed in the dorsal raphe nucleus and exhibited firing patterns distinctfrom those of the typical neurons, such as sustained tonic activity duringparadoxical sleep (types I-C and II-C) or showing their highest rate of tonic discharge during slow-wave sleep, with suppression of discharge during both waking and paradoxical sleep (type II-B). From these data we suggest that presumed serotonergic dorsal raphe neuronsplay different roles in behavioral state control and that there is functional topographic organization in the dorsal raphe nucleus, (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:17:09