Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differential emotional experience induces elevated spine densities on basal dendrites of pyramidal neurons in the anterior cingulate cortex of Octodon degus
Autore:
Helmeke, C; Poeggel, G; Braun, K;
Indirizzi:
Otto Von Guericke Univ, Leibniz Inst Neurobiol, D-39008 Magdeburg, GermanyOtto Von Guericke Univ Magdeburg Germany D-39008 9008 Magdeburg, Germany Otto Von Guericke Univ, Dept Zool & Dev Neurobiol, D-39008 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39008 9008 Magdeburg, Germany Univ Leipzig, Dept Human Biol, D-04103 Leipzig, Germany Univ Leipzig Leipzig Germany D-04103 uman Biol, D-04103 Leipzig, Germany
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 104, anno: 2001,
pagine: 927 - 931
SICI:
0306-4522(2001)104:4<927:DEEIES>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIAPHORASE-REACTIVE NEURONS; EARLY SOCIAL DEPRIVATION; QUANTITATIVE CHANGES; MATERNAL SEPARATION; PREFRONTAL CORTEX; SYNAPTIC DENSITY; PLASTICITY; NEOCORTEX; MONKEY; FIELD;
Keywords:
juvenile experience; cortical development; limbic cortex; dendritic spines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Braun, K Otto Von Guericke Univ, Leibniz Inst Neurobiol, Dept Zool Dev Neurobiol, Brenneckestr 6, D-39118 Magdeburg, Germany Otto Von Guericke Univ Brenneckestr 6 Magdeburg Germany D-39118
Citazione:
C. Helmeke et al., "Differential emotional experience induces elevated spine densities on basal dendrites of pyramidal neurons in the anterior cingulate cortex of Octodon degus", NEUROSCIENC, 104(4), 2001, pp. 927-931

Abstract

It appears likely that, in analogy to the synaptic development of sensory and motor cortices, which critically depends on sensory or motor stimulation (Rosenzweig and Bennett, 1996), the synaptic development of limbic cortical regions are modulated by early postnatal cognitive and emotional experiences. The very first postnatal experience, which takes place in a confined and stable familial environment, is the interaction of the newborn individual with the parents and siblings (Gray, 1958). The aim of this quantitativemorphological study was to analyze the impact of different degrees of juvenile emotional experience on the synaptic development in a limbic cortical area, the dorsal anterior cingulate cortex, a region which is involved in the perception and regulation of emotions. We study the precocious trumpet-tailed rat (Octodon degus) as the animal model, because, like human babies, this species is born with functional visual and acoustic systems and the pups are therefore capable of detecting even subtle environmental changes immediately after birth (Reynolds and Wright, 1979; Poeggel and Braun, 1996; Braun et al., 2000; Ovtscharoff and Braun, 2001). The results demonstrate that already a subtle disturbance of the familial environment such as handling induced Significantly elevated spine densities on the basal dendrites of layer III cortical pyramidal neurons. More severe disturbances of the emotional environment, such as periodic parental deprivation with or without subsequent chronic social isolation, resulted in an elevation of spine densities of similar magnitude as seen after handling and in addition, altered spine densities confined to specific dendritic segments were observed in thesegroups. These observations unveil the remarkable sensitivity of the dorsalanterior cingulate cortex towards environmental influences and behavioral experiences during phases of postnatal development. The behavioral consequences of these experience-induced synaptic changes still need to be analyzedfurther to assess if they are beneficial or detrimental to the animals cognitive and emotional capacities in later life. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:11:05