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Titolo:
Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease
Autore:
Gonzalez-Lima, F; Berndt, JD; Valla, JE; Games, D; Reiman, EM;
Indirizzi:
Univ Texas, Inst Neurosci, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Texas, Inst Neurosci, Austin, TX 78712 USA Univ Texas, Dept Psychol, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 Texas, Dept Psychol, Austin, TX 78712 USA Harrington Res Ctr, Alzheimers Dis Res Lab, Phoenix, AZ 85006 USA Harrington Res Ctr Phoenix AZ USA 85006 is Res Lab, Phoenix, AZ 85006 USA Elan Pharmaceut, S San Francisco, CA USA Elan Pharmaceut S San Francisco CA USA armaceut, S San Francisco, CA USA Univ Arizona, Dept Psychiat, Phoenix, AZ 85006 USA Univ Arizona Phoenix AZ USA 85006 a, Dept Psychiat, Phoenix, AZ 85006 USA Good Samaritan Reg Med Ctr, Positron Emiss Tomog Ctr, Phoenix, AZ 85006 USA Good Samaritan Reg Med Ctr Phoenix AZ USA 85006 tr, Phoenix, AZ 85006 USA
Titolo Testata:
NEUROREPORT
fascicolo: 11, volume: 12, anno: 2001,
pagine: 2375 - 2379
SICI:
0959-4965(20010808)12:11<2375:RCCFAH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID-PRECURSOR PROTEIN; NEUROPATHOLOGICAL CRITERIA; NEURONAL LOSS; MICE; ABNORMALITIES; DIAGNOSIS; DEPOSITS; PATTERN; DEFECTS;
Keywords:
Alzheimer's disease; amyloid precursor protein; corpus callosum; fornix; hippocampus; transgenic models;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Gonzalez-Lima, F Univ Texas, Inst Neurosci, Mezes Hall 330, Austin, TX 78712 USA Univ Texas Mezes Hall 330 Austin TX USA 78712 X 78712 USA
Citazione:
F. Gonzalez-Lima et al., "Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease", NEUROREPORT, 12(11), 2001, pp. 2375-2379

Abstract

Persons with Alzheimer's disease (AD) have progressive reductions in the relative sizes of the corpus callosum and hippocampus. Homozygotic PDAPP transgenic mice over-expressing a mutant form of the human amyloid precursor protein have more pronounced reductions in these regions, which are apparentprior to the deposition of amyloid plaques and do not progress with advancing age. The length of the corpus callosum was reduced by two-thirds, the fornix commissure was negligible, and the hippocampal volume was reduced by one-third, suggesting a massive disconnection between the cerebral hemispheres and the hippocampi in PDAPP mice. These findings, which might account for the early, nonprogressive behavioral abnormalities observed in these animals, have implications for the study of AD. NeuroReport 12:2375-2379 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 23/01/20 alle ore 06:26:52