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Titolo:
Enhancing fMRI contrast in awake-behaving primates using intravascular magnetite dextran nanopartieles
Autore:
Dubowitz, DJ; Bernheim, KA; Chen, DY; Bradley, WG; Andersen, RA;
Indirizzi:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Div Biol, Pasadena, CA 91125 USA Long Beach Mem Med Ctr, Long Beach Mem MRI Ctr, Long Beach, CA 90806 USA Long Beach Mem Med Ctr Long Beach CA USA 90806 , Long Beach, CA 90806 USA
Titolo Testata:
NEUROREPORT
fascicolo: 11, volume: 12, anno: 2001,
pagine: 2335 - 2340
SICI:
0959-4965(20010808)12:11<2335:EFCIAP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN VISUAL-CORTEX; BLOOD-VOLUME; FUNCTIONAL MRI; HUMAN BRAIN; STIMULATION; SEPARATION; ACTIVATION; RAT;
Keywords:
cerebral blood volume; feridex; fMRI; functional activation; magnetite; rhesus macaque monkey; visual cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Dubowitz, DJ CALTECH, Div Biol, 216-76, Pasadena, CA 91125 USA CALTECH 216-76 Pasadena CA USA 91125 , Pasadena, CA 91125 USA
Citazione:
D.J. Dubowitz et al., "Enhancing fMRI contrast in awake-behaving primates using intravascular magnetite dextran nanopartieles", NEUROREPORT, 12(11), 2001, pp. 2335-2340

Abstract

Functional MRI in awake-behaving primates is an emerging tool for bridgingthe gap between human fMRI and neurophysiology information from nonhuman primates. We report the use of magnetite dextran nanoparticles (Feridex) as a blood-pool agent to enhance fMRI contrast-to-noise (CNR) in primate FMRI The intravascular half-life of the magnetite dextran was long compared to lanthanide chelates (T-1/2 = 198 min) with shortened T-2 relaxation observedin blood and cerebral cortex. Greater than 3-fold enhancement in the percentage MR signal change was observed using nanoparticles (13%) compared withconventional BOLD fMRI (4%). The calculated regional cerebral blood volumein macaque primary visual cortex increased 32% with photic stimulation. The increased CNR allows greater flexibility in the design of awake-behaving primate fMRI studies with the potential for improvements in resolution and significantly shortened imaging times. NeuroReport 12:2335-2340 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 10:03:24