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Titolo:
Tyrosine hydroxylase, but not dopamine beta-hydroxylase, is increased in rat frontal cortex after traumatic brain injury
Autore:
Yan, HQ; Kline, AE; Ma, XC; Hooghe-Peters, EL; Marion, DW; Dixon, CE;
Indirizzi:
Univ Pittsburgh, Dept Neurosurg, Brain Trauma Res Ctr, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Res Ctr, Pittsburgh, PA 15260 USA Free Univ Brussels, Dept Pharmacol, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 col, B-1090 Brussels, Belgium
Titolo Testata:
NEUROREPORT
fascicolo: 11, volume: 12, anno: 2001,
pagine: 2323 - 2327
SICI:
0959-4965(20010808)12:11<2323:THBNDB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
WATER MAZE PERFORMANCE; PREFRONTAL CORTEX; NORADRENALINE; INNERVATION;
Keywords:
dopamine beta-hydroxylase (DBH); frontal cortex; immunohistochemistry; rat; traumatic brain injury (TBI); tyrosine hydroxylase (TH); Western blot;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Dixon, CE Univ Pittsburgh, Dept Neurosurg, Brain Trauma Res Ctr, 3434 5th Ave,Suite 201, Pittsburgh, PA 15260 USA Univ Pittsburgh 3434 5th Ave,Suite 201 Pittsburgh PA USA 15260 A
Citazione:
H.Q. Yan et al., "Tyrosine hydroxylase, but not dopamine beta-hydroxylase, is increased in rat frontal cortex after traumatic brain injury", NEUROREPORT, 12(11), 2001, pp. 2323-2327

Abstract

Chronic frontal lobe functional deficits after traumatic brain injury (TBI) may be associated with altered catecholamine systems in the frontal cortex. To test this, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) levels were examined by immunohistochemistry and Western blot at 1, 7, 14, and 28 days after TBI or sham surgery. No alterations in DBH levels were observed by Western blot at any time point examined, but there was a significant increase in TH expression 28 days after TBI (optical density 334 +/- 68% or 3.3-fold, ipsilateral and 218 +/- 39% or 2.2-fold. contralateral) relative to the sham controls. The increase in TH may reflect a compensatory response of dopaminergic neurons to upregulate their synthesizing capacity and increase the efficiency of dopamine neurotransmission chronically after TBI. NeuroReport 12:2323-2327 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 22/01/20 alle ore 06:25:56