Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chloride accumulation and depletion during GABA(A) receptor activation in neocortex
Autore:
DeFazio, RA; Hablitz, JJ;
Indirizzi:
Univ Alabama, Dept Neurobiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Neurobiol, Birmingham, AL 35294 USA
Titolo Testata:
NEUROREPORT
fascicolo: 11, volume: 12, anno: 2001,
pagine: 2537 - 2541
SICI:
0959-4965(20010808)12:11<2537:CAADDG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL PYRAMIDAL CELLS; IONIC MECHANISMS; RESPONSES; NEURONS; STIMULATION; CLAMP; CL;
Keywords:
chloride channels; chloride homeostasis; GABA; interneurons; neocortex; pyramidal cells; whole cell recording;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Hablitz, JJ Univ Alabama, Dept Neurobiol, CIRC510, Birmingham, AL 35294 USA Univ Alabama CIRC510 Birmingham AL USA 35294 ham, AL 35294 USA
Citazione:
R.A. DeFazio e J.J. Hablitz, "Chloride accumulation and depletion during GABA(A) receptor activation in neocortex", NEUROREPORT, 12(11), 2001, pp. 2537-2541

Abstract

The response of neocortical neurons to GABA is strongly influenced by the intracellular chloride concentration. We tested the hypothesis that activation of GABA(A) receptors can result in either depletion or accumulation of intracellular chloride. The measured reversal potentials of currents evokedby exogenously applied or synaptically released GABA were not significantly different. During GABA responses, voltage steps to the reversal potentialrevealed prominent tail-like currents. The polarity of these currents was opposite to that of the GABA-evoked currents, consistent with either accumulation or depletion of intracellular chloride. These results demonstrate that currents evoked by exogenously applied and synaptically released GABA share similar ionic dependencies. Current fluxes during GABA(A) receptor activation can be sufficiently large to change the intracellular chloride concentration, NeuroReport 12:2537-2541 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:23:04