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Titolo:
Microglial signaling by amyloid beta protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS
Autore:
Hasegawa, H; Nakai, M; Tanimukai, S; Taniguchi, T; Terashima, A; Kawamata, T; Fukunaga, K; Miyamoto, E; Misaki, K; Mukai, H; Tanaka, C;
Indirizzi:
Hyogo Inst Aging Brain & Cognit Disorders, Himeji, Hyogo 6700981, Japan Hyogo Inst Aging Brain & Cognit Disorders Himeji Hyogo Japan 6700981 apan Kumamoto Univ, Sch Med, Dept Pharmacol, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 Pharmacol, Kumamoto 8600811, Japan Kobe Univ, Grad Sch Sci & Technol, Kobe, Hyogo 6578501, Japan Kobe Univ Kobe Hyogo Japan 6578501 & Technol, Kobe, Hyogo 6578501, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 11, volume: 12, anno: 2001,
pagine: 2567 - 2571
SICI:
0959-4965(20010808)12:11<2567:MSBABP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; C SUBSTRATE; CELLS; STIMULATION; BRAINS;
Keywords:
amyloid beta protein (A beta); extracellular regulated kinase (ERK); microglia; mitogen-activated protein kinase (MAPK); myristoylated alanine-rich C kinase substrate (MARCKS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, C Hyogo Inst Aging Brain & Cognit Disorders, 520 Saisho Ko, Himeji, Hyogo 6700981, Japan Hyogo Inst Aging Brain & Cognit Disorders 520 SaishoKo Himeji Hyogo Japan 6700981
Citazione:
H. Hasegawa et al., "Microglial signaling by amyloid beta protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS", NEUROREPORT, 12(11), 2001, pp. 2567-2571

Abstract

Myristoylated alanine-rich C kinase substrate (MARCKS), an acidic protein associated with cell motility and phagocytosis, is activated upon phosphorylation by protein kinase C (PKC) and proline-directed protein kinases. In Alzheimer disease (AD), activated microglia expressing MARCKS migrates around senile plaques. We reported that amyloid beta protein (A beta), a major component of senile plaques, activated MARCKS through a tyrosine kinase and PKC-delta. We have now identified another A beta signaling pathway through a mitogen-activated protein kinase (MAPK) involved in the phosphorylation of MARCKS and analysed cross-talk between PKC and MAPK pathways in primary cultured rat microglia. A selective inhibitor for MAPK kinase, PD098059, significantly inhibited the phosphorylation of MARCKS induced by A beta, Extracellulary regulated kinases, the activities of which were induced by A beta, directly phosphorylated a recombinant MARCKS in vitro. The MAPK pathway was sensitive to wortmannin, but not to a PKC inhibitor or to tyrosine kinase inhibitors. The activation of PKC by A beta was not sensitive to wortmannin. Our findings suggest involvement of the MAPK pathway through phosphoinositol 3-kinase in the phosphorylation of MARCKS in rat cultured microglia, an event may be associated with mechanisms activating microglia in AD. NeuroReport 12:2567-2571 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:00:21