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Titolo:
Delayed application of IGF-1 and GDNF can rescue already injured postnatalmotor neurons
Autore:
Bilak, MM; Kuncl, RW;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 Neurol, Baltimore, MD 21287 USA
Titolo Testata:
NEUROREPORT
fascicolo: 11, volume: 12, anno: 2001,
pagine: 2531 - 2535
SICI:
0959-4965(20010808)12:11<2531:DAOIAG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; INDUCED CELL-DEATH; GROWTH-FACTOR-I; NEUROTROPHIC FACTOR PREVENTS; SPINAL-CORD; TYROSINE KINASE; RECEPTOR; MOTONEURONS; RET; DEGENERATION;
Keywords:
ALS; delayed application; glutamate toxicity; neurodegeneration; neurotrophic factors; synergy; tissue culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kuncl, RW Johns Hopkins Univ, Sch Med, Dept Neurol, 600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Univ 600 N Wolfe St Baltimore MD USA 21287 287 USA
Citazione:
M.M. Bilak e R.W. Kuncl, "Delayed application of IGF-1 and GDNF can rescue already injured postnatalmotor neurons", NEUROREPORT, 12(11), 2001, pp. 2531-2535

Abstract

IGF-I, GDNF, and other neurotrophic factors, when applied at the time of injury, can protect postnatal motor neurons from slow glutamate injury in organotypic spinal cord. However, in human spinal cord diseases, motor neuroninjury is already established when treatment could begin. We tested whether neurotrophic factors can protect already-injured motor neurons, and whether combinations of factors can further lengthen the therapeutic time window. Our data show that during a 7-8 week process of slow neurodegeneration either IGF-I or GDNF treatment, though delayed up to 4 weeks, still allowed substantial rescue of already injured motor neurons. However, the combination of both factors additively provided better neuroprotection than either factor alone, even after a 4-week delay. This proof of principle is relevant to the potential of lGF-I and GDNF as therapy for acquired disorders affecting motor neurons. NeuroReport 12:2531-2535 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:39:05