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Titolo:
Exogenous glutamate induces short and long-term potentiation in the rat medial vestibular nuclei
Autore:
Grassi, S; Frondaroli, A; Pessia, M; Pettorossi, VE;
Indirizzi:
Univ Perugia, Dept Internal Med, Sect Human Physiol, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 Human Physiol, I-06100 Perugia, Italy Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, I-66030 Santa Maria Imbaro, Chieti, Italy Ist Ric Farmacol Mario Negri Santa Maria Imbaro Chieti Italy I-66030 taly
Titolo Testata:
NEUROREPORT
fascicolo: 11, volume: 12, anno: 2001,
pagine: 2329 - 2334
SICI:
0959-4965(20010808)12:11<2329:EGISAL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; SYNAPTIC TRANSMISSION; NITRIC-OXIDE; RECEPTORS; STIMULATION; DEPRESSION; EXOCYTOSIS; CA1;
Keywords:
exogenous glutamate; field potential; long-term potentiation; medial vestibular nuclei; short-term potentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Grassi, S Univ Perugia, Dept Internal Med, Sect Human Physiol, Via Giochetto 1, I-06100 Perugia, Italy Univ Perugia Via Giochetto 1 Perugia Italy I-06100 rugia, Italy
Citazione:
S. Grassi et al., "Exogenous glutamate induces short and long-term potentiation in the rat medial vestibular nuclei", NEUROREPORT, 12(11), 2001, pp. 2329-2334

Abstract

In rat brain stem slices, high concentrations of exogenous glutamate induce long-term potentiation (LTP) of the field potentials evoked in the medialvestibular nuclei (MVN) by vestibular afferent stimulation. At low concentrations, glutamate can also induce short-term potentiation (STP), indicating that LTP and STP are separate events depending on the level of glutamatergic synapse activation. LTP and STP are prevented by blocking NMDA receptors and nitric oxide (NO) synthesis. Conversely, blocking platelet-activatingfactor (PAF) and group I metabotropic glutamate receptors only prevents the full development of LTP. Moreover, in the presence of blocking agents, glutamate causes transient inhibition, suggesting that when potentiation is impeded, exogenous glutamate can activate presynaptic mechanisms that reduceglutamate release. NeuroReport 12:2329-2334 (C) 2001 Lippincott Williams &Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:58:53