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Titolo:
Decrease in N-acetylaspartate/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis
Autore:
Abe, K; Takanashi, M; Watanabe, Y; Tanaka, H; Fujita, N; Hirabuki, N; Yanagihara, T;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Neurol, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 ch Med, Dept Neurol, Osaka 5650871, Japan Osaka Univ, Grad Sch Med, Dept Radiol, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 ch Med, Dept Radiol, Osaka 5650871, Japan
Titolo Testata:
NEURORADIOLOGY
fascicolo: 7, volume: 43, anno: 2001,
pagine: 537 - 541
SICI:
0028-3940(200107)43:7<537:DINRIT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; NEURON DISEASE; COGNITIVE FUNCTION; AMINO-ACIDS; ALS; GLUTAMATE; BRAIN;
Keywords:
motor neurone disease; N-acetylaspartate; magnetic resonance spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, K Osaka Univ, Grad Sch Med, Dept Neurol, D-4,2-2 Yamadaoka, Osaka 5650871, Japan Osaka Univ D-4,2-2 Yamadaoka Osaka Japan 5650871 ka 5650871, Japan
Citazione:
K. Abe et al., "Decrease in N-acetylaspartate/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis", NEURORADIOL, 43(7), 2001, pp. 537-541

Abstract

We studied whether N-acetylaspartate (NAA), a neuronal marker, is reduced in the brain of 14 patients with clinically definite amyotrophic lateral sclerosis (ALS) and whether NAA levels in the motor area and frontal lobe correlate with the clinical features, including frontal lobe function. We alsostudied 14 normal controls were evaluated. We obtained peak integrals in H-1 magnetic resonance spectroscopy (MRS) for NAA, creatine (Cr), and choline-containing compounds (Cho). Severity of the disease was determined using the manual muscle strength test, and the Norris limb and bulbar scales. In the patients, the NAA/Cr ratio was reduced in the motor area and frontal lobe, while the Cho/Cr ratio was normal throughout the brain. There were significant correlations between the NAA/Cr ratio in the motor area and the Norris limb scale (r = 0.50; P < 0.01) and between the NAA/Cr ratio in the frontal lobe and the number of categories achieved in the Wisconsin Card Sorting test (r = 0.71; P < 0.05), implying frontal lobe dysfunction. These correlations suggest that a reduced NAA/Cr ratio is a marker of cortical neuronal loss and dysfunction in ALS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:37:29