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Titolo:
Ultradian and circadian body temperature and activity rhythms in chronic MPTP treated monkeys
Autore:
Almirall, H; Bautista, V; Sanchez-Bahillo, A; Trinidad-Herrero, M;
Indirizzi:
Univ Barcelona, Dept Psiquiatria & Psicobiol Clin, Barcelona, Spain Univ Barcelona Barcelona Spain atria & Psicobiol Clin, Barcelona, Spain Univ Murcia, Murcia, Spain Univ Murcia Murcia SpainUniv Murcia, Murcia, Spain
Titolo Testata:
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
fascicolo: 3, volume: 31, anno: 2001,
pagine: 161 - 170
SICI:
0987-7053(200106)31:3<161:UACBTA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLEEP; PARKINSONISM; SECONDARY; NEURONS;
Keywords:
activity level; body temperature; circadian rhythm; differential vulnerability; monkey; motor disability; MPTP; nigrostriatal system; Parkinson's disease; sleep; ultradian rhythm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Almirall, H Univ Barcelona, Dept Psiquiatria & Psicobiol Clin, Barcelona, Spain Univ Barcelona Barcelona Spain obiol Clin, Barcelona, Spain
Citazione:
H. Almirall et al., "Ultradian and circadian body temperature and activity rhythms in chronic MPTP treated monkeys", NEUROP CLIN, 31(3), 2001, pp. 161-170

Abstract

The body temperature and locomotor activity rhythms of seven 1-Methyl, 4-phenyl, 1,2,3,6-tetrahydropyridine (MPTP)-treated cynomolgous monkeys were registered over a week on two separate occasions over an interval of 2 months. Motor disability was absent in two animals and present in five: it was mild in one, moderate in two and severe in two. Both temperature and motor activity were recorded every minute using a radio telemetry system. Analysisof circadian rhythms revealed less robustness of the 24-hour circadian components of body temperature and locomotor activity with increasing motor impairment, and a fragmentation of the body temperature rhythm into 8 hour-period components. Both total activity and daytime activity correlated inversely with the degree of motor impairment, On the contrary, the monkeys did not show differences in night time activity. The proportions of variance accounted for by the body temperature and locomotor activity of 24 h + 12 h + 8 h components were correlated. Also, the average levels at which the circadian rhythm varies between body temperature and locomotor activity were correlated, The results were almost identical in the two 1-week recording sessions. The present study confirms individual differences in the vulnerability to MPTP of the nigrostriatal system of monkeys, suggesting that if a cumulative dose does not provoke stable motor alterations, this cumulative dose willnot produce circadian body temperature and locomotor activity rhythm alterations either. Similarly, if a dose is able to produce motor impairment, this dose will also be able to produce circadian rhythm alterations. (C) 2001Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:00:16