Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
In vivo short echo time H-1-magnetic resonance spectroscopic imaging (MRSI) of the temporal lobes
Autore:
McLean, MA; Woermann, FG; Simister, RJ; Barker, GJ; Duncan, JS;
Indirizzi:
Natl Soc Epilepsy, MRI Unit, London, England Natl Soc Epilepsy London England oc Epilepsy, MRI Unit, London, England Inst Neurol, Univ Dept Clin Neurol, Epilepsy Res Grp, London WC1N 3BG, England Inst Neurol London England WC1N 3BG sy Res Grp, London WC1N 3BG, England Univ Coll London, Inst Neurol, Multiple Sclerosis NMR Res Unit, London, England Univ Coll London London England Sclerosis NMR Res Unit, London, England
Titolo Testata:
NEUROIMAGE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 501 - 509
SICI:
1053-8119(200108)14:2<501:IVSETH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCALIZED PROTON MRS; HUMAN BRAIN; METABOLITE CONCENTRATIONS; PRESURGICAL LOCALIZATION; WHITE-MATTER; 4.1 T; EPILEPSY; LATERALIZATION; H-1-MRSI; PROFILE;
Keywords:
H-1-MRSI; human brain; temporal lobes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: McLean, MA Natl Soc Epilepsy, MRI Unit, Queen Sq, London, England Natl SocEpilepsy Queen Sq London England Sq, London, England
Citazione:
M.A. McLean et al., "In vivo short echo time H-1-magnetic resonance spectroscopic imaging (MRSI) of the temporal lobes", NEUROIMAGE, 14(2), 2001, pp. 501-509

Abstract

Two different methodologies for obtaining PRESS-localized magnetic resonance spectroscopic imaging (MRSI) data from the mesial and lateral temporal lobes were investigated. The study used short echo times (30 ms) and long repetition times (3000 ms) to minimize relaxation effects. Inhomogeneity and spectral distortions from the proximity of the temporal bones precluded theattainment of consistently good-quality data from both temporal lobes at once. Even when the right and left temporal lobes were studied separately, distortions often disturbed spectra from the anterior lateral temporal lobe. Quantitative analysis using LCModel was therefore performed only on the posterior lateral temporal lobe, and the posterior, middle, and anterior mesial temporal lobe. No significant left-right differences in metabolite content were found in a series of 10 controls. Significantly higher concentrations of myoinositol and choline were found in the anterior mesial temporal lobe, even when grey matter content was included as a covariate. The concentration of N-acetyl aspartate plus N-acetyl aspartyl glutamate (NAc) was not found to vary significantly along the length of the hippocampus. The previously observed lower anterior ratios of NAA to creatine plus choline (NAA/(Cr + Cho) may instead have been due to higher anterior choline. Large differences in metabolite concentrations were seen between posterior lateral temporal lobe (predominantly subcortical white matter) and the posterior mesialtemporal lobe, most notably lower creatine, glutamate/glutamine, and myo-inositol, and higher NAA/(Cr + Cho) in the lateral than mesial temporal lobe. This pattern was similar to that previously seen for grey/white matter differences in the frontal, parietal and occipital regions. (C) 2001 AcademicPress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:55:07