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Titolo:
Interhemispheric differences of sensory hand areas after monohemispheric stroke: MEG/MRI integrative study
Autore:
Rossini, PM; Tecchio, F; Pizzella, V; Lupoi, D; Cassetta, E; Paqualetti, P;
Indirizzi:
Ist Sacro Cuore Gesu, Ctr S Giovanni di Dio, IRCCS, Brescia, Italy Ist Sacro Cuore Gesu Brescia Italy ovanni di Dio, IRCCS, Brescia, Italy Osp Fatebenefratelli, Dipartimento Neurosci, CRCCS, AFaR, Rome, Italy Osp Fatebenefratelli Rome Italy ento Neurosci, CRCCS, AFaR, Rome, Italy CNR, Ist Elettron Stato Solido, Rome, Italy CNR Rome ItalyCNR, Ist Elettron Stato Solido, Rome, Italy Univ G dAnnunzio, ITAB, Chieti, Italy Univ G dAnnunzio Chieti ItalyUniv G dAnnunzio, ITAB, Chieti, Italy Univ G dAnnunzio, Ist Fis Med, Chieti, Italy Univ G dAnnunzio Chieti Italy v G dAnnunzio, Ist Fis Med, Chieti, Italy Dept Neurol, Rome, Italy Dept Neurol Rome ItalyDept Neurol, Rome, Italy
Titolo Testata:
NEUROIMAGE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 474 - 485
SICI:
1053-8119(200108)14:2<474:IDOSHA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED MAGNETIC-FIELDS; MEDIAN NERVE-STIMULATION; MOTOR CORTEX; PARTIAL DEAFFERENTATION; ELECTRICAL-STIMULATION; SOURCE LOCALIZATION; CENTRAL SULCUS; HUMAN-BRAIN; RECOVERY; MONKEYS;
Keywords:
stroke; plastic reorganization; magnetoencephalography (MEG); somatosensory-evoked fields (SEF); magnetic resonance imaging (MRI);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Rossini, PM Ist Sacro Cuore Gesu, Ctr S Giovanni di Dio, IRCCS, Via Pilastroni, Brescia, Italy Ist Sacro Cuore Gesu Via Pilastroni Brescia Italy cia, Italy
Citazione:
P.M. Rossini et al., "Interhemispheric differences of sensory hand areas after monohemispheric stroke: MEG/MRI integrative study", NEUROIMAGE, 14(2), 2001, pp. 474-485

Abstract

Seventeen clinically stabilized monohemispheric stroke patients were studied in order to investigate the chronic topographical modifications induced on primary sensory cortical hand areas by a monohemispheric stroke within the middle cerebral artery territory. Magnetoencephalographic (MEG) localization of the cortical areas activated following electrical separate stimulation of the median nerve, thumb, and little fingers was integrated with magnetic resonance imaging. Spatial localization of Equivalent Current Dipoles (ECDs) of the short-latency cortical responses generated in primary sensorycortices, "hand area" (distance between 1st and 5th digits ECDs), interhemispheric differences of such parameters, as well as of somatosensory-evokedfields waveshapes were investigated and compared with a control population. Lesions involving the cortico-subcortical areas receiving sensory input from the hand induced excessive asymmetry of MEG spatial parameters and response morphology between the unaffected (UH) and the affected hemisphere (AH). "Hand area" was significantly larger on AH in 20% of cases after a subcortical, and in 13% after a cortical, lesion. Responses from AH were excessively delayed in 20% ECDs. Interhemispheric ECDs strength differences were larger than normal in 25% of cases after both types of lesions; the strengthin the AH being enlarged after all cortical, and only 24% of subcortical strokes. In a significant percentage of monohemispheric strokes, excessive interhemispheric differences were found between AH and UH, suggesting that brain areas outside the normal boundaries and usually not reached by a densesensory input from the opposite hand and fingers may act as somatosensory "hand" centers. Correlation analysis between clinical outcome and cortical reorganization in the AH suggests that this mechanism is linked with hand sensorimotor recovery. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:27:34