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Titolo:
Alteration in cytoskeletal protein levels in sciatic nerve on post-treatment of diisopropyl phosphorofluoridate (DFP)-treated hen with phenylmethylsulfonyl fluoride
Autore:
Xie, KQ; Gupta, RP; Abou-Donia, MB;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol & Canc BIol, Durham, NC 27708 USA Duke Univ Durham NC USA 27708 Pharmacol & Canc BIol, Durham, NC 27708 USA Univ Sci & Technol China, Sch Life Sci, Neurotoxicol Lab, Hefei 230027, Anhui, Peoples R China Univ Sci & Technol China Hefei Anhui Peoples R China 230027 oples R China
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 3, volume: 26, anno: 2001,
pagine: 235 - 243
SICI:
0364-3190(200103)26:3<235:AICPLI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DELAYED NEUROTOXICITY; SPINAL-CORD; NEUROFILAMENT PROTEINS; EXPRESSION; AXONS; AGGREGATIONS; POTENTIATION; SUBUNITS; DISEASE; HEALTH;
Keywords:
DFP; sciatic nerve; chickens; PMSF; OPIDN; NF-H; NF-M; NF-L;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Abou-Donia, MB Duke Univ, Med Ctr, Dept Pharmacol & Canc BIol, POB 3813, Durham, NC 27708USA Duke Univ POB 3813 Durham NC USA 27708 Durham, NC 27708USA
Citazione:
K.Q. Xie et al., "Alteration in cytoskeletal protein levels in sciatic nerve on post-treatment of diisopropyl phosphorofluoridate (DFP)-treated hen with phenylmethylsulfonyl fluoride", NEUROCHEM R, 26(3), 2001, pp. 235-243

Abstract

Diisopropyl phosphorofluoridate (DFP) is an organophosphorus ester, and a single dose (1.7 mg/kg, sc.) of this compound produces mild ataxia in hens in 7-14 days and a severe ataxia or paralysis (OPIDN) in three weeks. OPIDNis associated with axonal swelling and their degeneration. We have previously observed alteration in neurofilament (NF) protein levels in the spinal cord of DFP-treated hens. The main objective of this investigation was to study NF protein levels in the sciatic nerves (SN) of hens, in which OPIDN has been potentiated by phenylmethylsulfonyl fluoride (PMSF) post-treatment. PMSF is known to protect DFP-treated (1.7 mg/kg) hens from developing OPIDN if injected before, and potentiate OPIDN if injected after the administration of DFP (0.5 mg/kg). The potentiation of OPIDN was accompanied by earlier elevation of NF proteins in the SN particulate fraction. In contrast, SNsupernatant fraction showed a transient fall in NF protein levels in potentiation OPIDN. Out of the two other cytoskeletal proteins (i.e., tubulin, tau) studied in this investigation, tubulin also showed earlier elevation inits level in the particulate fraction in potentiated OPIDN. The earlier elevation of NF protein levels in SN particulate fraction in potentiated OPIDN suggested the possible involvement of NFs in delayed neurotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:24:02