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Titolo:
Seizure activity produces differential changes in adenosine A(1) receptorswithin rat hippocampus
Autore:
Vanore, G; Giraldez, L; Arnaiz, GRD; Girardi, E;
Indirizzi:
Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencias Prof EduardoDe, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1121 Aires, DF, Argentina
Titolo Testata:
NEUROCHEMICAL RESEARCH
fascicolo: 3, volume: 26, anno: 2001,
pagine: 225 - 230
SICI:
0364-3190(200103)26:3<225:SAPDCI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVULSANT 3-MERCAPTOPROPIONIC ACID; 5'-NUCLEOTIDASE ACTIVITY; SUBCELLULAR-FRACTIONS; MOUSE-BRAIN; EPILEPSY; CYCLOPENTYLADENOSINE; ORGANIZATION; MECHANISMS; INCREASES; LIGANDS;
Keywords:
hippocampus; seizure; adenosine A(1) receptors; epilepsy; autoradiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Girardi, E Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencias Prof EduardoDe, Paraguay 2155, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Paraguay 2155 Buenos Aires DF Argentina RA-1121
Citazione:
G. Vanore et al., "Seizure activity produces differential changes in adenosine A(1) receptorswithin rat hippocampus", NEUROCHEM R, 26(3), 2001, pp. 225-230

Abstract

Specific ligand binding to rat hippocampal adenosine A(1) receptor after administration of the convulsant drug 3-mercaptopropionic acid (MP) was studied by means of a quantitative autoradiographic method. 2-Chloro-N6-[cyclopentyl-2,3,4,5-H-3 adenosine] ([H-3]CCPA), a potent and selective A(1) receptor ligand, was selected for binding studies. MP administration (150 mg/kg,i.p.), at seizure, caused significant increases in the following CAI layers: pyramidal (45%), radiatum (18%) and lacunosum molecular (35%); in CA2 area, a significant decrease in stratum oriens (36%) and an increase in stratum radiatum (14%) and lacunosum molecular (33%) layers was observed. In CA3area a rise in pyramidal (40%) and radiatum layers (26%), as well as in hillus (97%) was found. At postseizure, changes were restricted to CAI, CA2 and CA3 pyramidal layers and to CAI lacunosum molecular layer, with increases ranging from 22 to 50%. These results show that [H-3]CCPA binding is modified diversely in intrahippocampal layers and areas, thus indicating their dissimilar role in seizure activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:16:10