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Titolo:
Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
Autore:
Parri, HR; Gould, TM; Crunelli, V;
Indirizzi:
Cardiff Univ, Sch Biosci, Cardiff CF10 3US, S Glam, Wales Cardiff Univ Cardiff S Glam Wales CF10 3US ardiff CF10 3US, S Glam, Wales
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 8, volume: 4, anno: 2001,
pagine: 803 - 812
SICI:
1097-6256(200108)4:8<803:SACOIS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED HIPPOCAMPAL-NEURONS; DEPENDENT GLUTAMATE RELEASE; GLIAL CALCIUM WAVES; SYNAPTIC TRANSMISSION; POSTNATAL-DEVELOPMENT; REGIONAL EXPRESSION; RAT-BRAIN; IN-SITU; RECEPTORS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Crunelli, V Cardiff Univ, Sch Biosci, Museum Ave,POB 911, Cardiff CF10 3US, S Glam, Wales Cardiff Univ Museum Ave,POB 911 Cardiff S Glam Wales CF10 3US
Citazione:
H.R. Parri et al., "Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation", NAT NEUROSC, 4(8), 2001, pp. 803-812

Abstract

Astrocytes respond to chemical, electrical and mechanical stimuli with transient increases in intracellular calcium concentration ([Ca2+](i)). We nowshow that astrocytes in situ display intrinsic [Ca2+](i) oscillations thatare not driven by neuronal activity. These spontaneous astrocytic oscillations can propagate as waves to neighboring astrocytes and trigger slowly decaying NMDA receptor-mediated inward currents in neurons located along the wave path. These findings show that astrocytes in situ can act as a primarysource for generating neuronal activity in the mammalian central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:49:12