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Titolo:
Glutamate regulates actin-based motility in axonal filopodia
Autore:
Chang, S; De Camilli, P;
Indirizzi:
Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06515 USA Yale Univ New Haven CT USA 06515 Hughes Med Inst, New Haven, CT 06515 USA Yale Univ, Sch Med, Boyer Ctr Mol Med, Dept Cell Biol, New Haven, CT 06515USA Yale Univ New Haven CT USA 06515 , Dept Cell Biol, New Haven, CT 06515USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 8, volume: 4, anno: 2001,
pagine: 787 - 793
SICI:
1097-6256(200108)4:8<787:GRAMIA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESYNAPTIC KAINATE RECEPTORS; HIPPOCAMPAL PYRAMIDAL NEURONS; DENDRITIC SPINES; SYNAPTIC VESICLES; CALCIUM DYNAMICS; SYNAPTOGENESIS; SYNAPSES; CHANNELS; RECRUITMENT; PLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: De Camilli, P Yale Univ, Sch Med, Howard Hughes Med Inst, 295 Congress Ave,POB 9812, NewHaven, CT 06515 USA Yale Univ 295 Congress Ave,POB 9812 New Haven CT USA 06515 A
Citazione:
S. Chang e P. De Camilli, "Glutamate regulates actin-based motility in axonal filopodia", NAT NEUROSC, 4(8), 2001, pp. 787-793

Abstract

The dynamics of axonal arbors during synaptogenesis and their plasticity in the adult nervous system remain poorly understood. Axonal filopodia, which emerge from the shaft of axonal branches and contain small synaptic vesicle clusters, initiate synaptic formation. We found that the movement of axonal filopodia is strongly inhibited by the neurotransmitter glutamate. Thisinhibitory effect is local, requires extracellular Ca2+, and can be blocked by CNQX treatment but not by NMDA, implicating axonal AMPA/kainate glutamate receptors. Transport and exo-endocytic recycling of synaptic vesicle packages in filopodia are not affected. These results reveal that the effect of glutamate on axonal filopodia is similar to its previously described effect on dendritic spines. Our results raise the possibility that axonal ionotropic glutamate receptors are also involved in synaptic plasticity in the adult nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:22:27