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Titolo:
CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein
Autore:
Tripp, RA; Jones, LP; Haynes, LM; Zheng, HQ; Murphy, PM; Anderson, LJ;
Indirizzi:
Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Resp & Enter Virus Branch, Atlanta, GA USA Natl Ctr Infect Dis Atlanta GA USA & Enter Virus Branch, Atlanta, GA USA NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 ID, Host Def Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 8, volume: 2, anno: 2001,
pagine: 732 - 738
SICI:
1529-2908(200108)2:8<732:CCMBRS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; BALB/C MICE; F-PROTEIN; CHEMOTACTIC RECEPTOR; VIRAL REPLICATION; TRACT DISEASE; RSV CHALLENGE; SUBGROUP-B; IN-VITRO; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Tripp, RA Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Resp & Enter Virus Branch, Mailstop G-09,1600 Clifton Rd, Atlanta, GA USA Natl Ctr InfectDis Mailstop G-09,1600 Clifton Rd Atlanta GA USA
Citazione:
R.A. Tripp et al., "CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein", NAT IMMUNOL, 2(8), 2001, pp. 732-738

Abstract

Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokineshave roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokine mimicry for the G glycoprotein of respiratory syncytial virus (RSV) and show binding to CX3CRI-the specific receptor for the CX3C chemokine fractalkine-and induction of leukocyte chemotaxis. We also showthat CX3CRI facilitates RSV infection of cells. Thus, G glycoprotein interaction with CX3CRI probably plays a key role in the biology of RSV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:05:00