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Titolo:
Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
Autore:
Akbari, O; DeKruyff, RH; Umetsu, DT;
Indirizzi:
Stanford Univ, Sch Med, Dept Pediat, Div Immunol & Allergy, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 nol & Allergy, Stanford, CA 94305 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 8, volume: 2, anno: 2001,
pagine: 725 - 731
SICI:
1529-2908(200108)2:8<725:PDCPIM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; MOUSE BONE-MARROW; CD4(+) T-CELLS; IN-VIVO; INTERFERON-GAMMA; IMMUNE DEVIATION; TH2 RESPONSES; INDUCTION; DIFFERENTIATION; INTERLEUKIN-10;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Umetsu, DT Stanford Univ, Sch Med, Dept Pediat, Div Immunol & Allergy, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 gy, Stanford, CA 94305 USA
Citazione:
O. Akbari et al., "Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen", NAT IMMUNOL, 2(8), 2001, pp. 725-731

Abstract

Respiratory exposure to allergen induces T cell tolerance and protection against the development of airway hyperreactivity and asthma. However, the specific mechanisms by which tolerance is induced by respiratory allergen are not clear. We report here that pulmonary dendritic cells (DCs) from mice exposed to respiratory antigen transiently produced interleukin 10 (IL-10). These phenotypically mature pulmonary DCs, which were B-7(hi) as well as producing IL-10, stimulated the development of CD4(+)T regulatory I-like cells that also produced high amounts of IL-10. In addition, adoptive transferof pulmonary DCs from IL-10(+/+), but not IL-10(-/-), mice exposed to respiratory antigen induced antigen-specific unresponsiveness in recipient mice. These studies show that IL-10 production by DCs is critical for the induction of tolerance, and that phenotypically mature pulmonary DCs mediate tolerance induced by respiratory exposure to antigen.

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Documento generato il 25/01/20 alle ore 15:42:05