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Titolo:
Functional avidity maturation of CD8(+)T cells without selection of higheraffinity TCR
Autore:
Slifka, MK; Whitton, JL;
Indirizzi:
Scripps Clin, Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA Scripps Clin La Jolla CA USA 92037 Neuropharmacol, La Jolla, CA 92037 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 8, volume: 2, anno: 2001,
pagine: 711 - 717
SICI:
1529-2908(200108)2:8<711:FAMOCC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; SIGNAL-TRANSDUCTION; RECEPTOR REPERTOIRE; CHORIOMENINGITIS VIRUS; VIRAL-INFECTION; ANTIGEN; MEMORY; CD8; COMPLEXES; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Slifka, MK OHSU, Vaccine & Gene Therapy Inst, Beaverton, OR 97006 USA OHSU Beaverton OR USA 97006 rapy Inst, Beaverton, OR 97006 USA
Citazione:
M.K. Slifka e J.L. Whitton, "Functional avidity maturation of CD8(+)T cells without selection of higheraffinity TCR", NAT IMMUNOL, 2(8), 2001, pp. 711-717

Abstract

Unlike B cells, T cells lack the capacity to improve the affinity of theirantigen receptors by somatic mutation. It is, therefore, believed that optimization of cellular immunity is mediated almost exclusively through selective expansion of T cells bearing receptors with the highest affinity for antigen. We show here that T cell responsiveness to peptide (termed "functional avidity") increased > 50-fold during the early stages of viral infection. This indicated that T cells, like B cells, undergo extensive functional maturation in vivo. However, in contrast to B cells, maturation of the T cell response can occur without any appreciable change in T cell receptor affinity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:54:11