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Titolo:
CD4(+) T cell effectors can become memory cells with high efficiency and without further division
Autore:
Hu, H; Huston, G; Duso, D; Lepak, N; Roman, E; Swain, SL;
Indirizzi:
Trudeau Inst Inc, Saranac Lake, NY 12983 USA Trudeau Inst Inc Saranac Lake NY USA 12983 nc, Saranac Lake, NY 12983 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 8, volume: 2, anno: 2001,
pagine: 705 - 710
SICI:
1529-2908(200108)2:8<705:CTCECB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA PROMOTER DEMETHYLATION; IN-VIVO PERSISTENCE; IMMUNOLOGICAL MEMORY; TRANSCRIPTION FACTOR; INTERFERON-GAMMA; CUTTING EDGE; IFN-GAMMA; ANTIGEN; GENERATION; NAIVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Swain, SL Trudeau Inst Inc, 100 Algonquin Ave, Saranac Lake, NY 12983 USA Trudeau Inst Inc 100 Algonquin Ave Saranac Lake NY USA 12983 USA
Citazione:
H. Hu et al., "CD4(+) T cell effectors can become memory cells with high efficiency and without further division", NAT IMMUNOL, 2(8), 2001, pp. 705-710

Abstract

Whether memory T lymphocytes are derived directly from effector T cells orvia a separately controlled pathway has long been debated. Here we presentevidence that, after adoptive transfer, a large fraction of in vitro-derived effector CD4(+)T cells have the potential to become memory T cells and that this transition can occur without further division. This data supports a linear pathway from effector to memory cells and suggests that most properties of memory cells are predetermined during effector generation. We suggest, therefore, that evaluation of vaccine efficacy in the induction of memory CD4(+)T cells should focus on the effector stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:26:42