Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Transcription factor LKLF is sufficient to program T cell quiescence via ac-Myc-dependent pathway
Autore:
Buckley, AF; Kuo, CT; Leiden, JM;
Indirizzi:
Univ Chicago, Comm Immunol, Chicago, IL 60637 USA Univ Chicago Chicago ILUSA 60637 go, Comm Immunol, Chicago, IL 60637 USA Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 niv, Sch Publ Hlth, Boston, MA 02115 USA Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Pritzker Sch Med, Chicago, IL 60637 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 8, volume: 2, anno: 2001,
pagine: 698 - 704
SICI:
1529-2908(200108)2:8<698:TFLIST>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
KRUPPEL-LIKE FACTOR; ACTIVATION; EXPRESSION; SURVIVAL; PROMOTER; IDENTIFICATION; ELONGATION; CYTOKINES; MOLECULE; ARREST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Buckley, AF Univ Chicago, Comm Immunol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 unol, Chicago, IL 60637 USA
Citazione:
A.F. Buckley et al., "Transcription factor LKLF is sufficient to program T cell quiescence via ac-Myc-dependent pathway", NAT IMMUNOL, 2(8), 2001, pp. 698-704

Abstract

T lymphocytes circulate in a quiescent state until they encounter cognate antigen bound to the surface of an antigen-presenting cell. The molecular pathways that regulate T cell quiescence remain largely unknown. Here we show that forced expression of the lung Kruppel-like transcription factor (LKLF) in jurkat T cells is sufficient to program a quiescent phenotype characterized by decreased proliferation, reduced cell size and protein synthesis and decreased surface expression of activation markers. Conversely, LKLF-deficient peripheral T cells produced by gene targeting showed increased proliferation, increased cell size and enhanced expression of surface activation markers in vivo. LKLF appeared to function, at least in part, by decreasing expression of the proto-oncogene encoding c-Myc. Forced expression of LKLF was associated with markedly decreased c-Myc expression. In addition, many effects of LKLF expression were mimicked by expression of the dominant-negative MadMyc protein and rescued by overexpression of c-Myc. Thus, LKLF is both necessary and sufficient to program quiescence in T cells and functions, in part, by negatively regulating a c-Myc-dependent pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:43:34