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Titolo:
The beta-catenin-TCF-I pathway ensures CD4(+)CD8(+) thymocyte survival
Autore:
Ioannidis, V; Beermann, F; Clevers, H; Held, W;
Indirizzi:
Univ Lausanne, Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland Univ Lausanne Epalinges Switzerland CH-1066 -1066 Epalinges, Switzerland Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland Swiss Inst Expt Canc Res Epalinges Switzerland CH-1066 nges, Switzerland Univ Utrecht Hosp, Dept Immunol, NL-3584 CX Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands NL-3584 CX CX Utrecht, Netherlands
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 8, volume: 2, anno: 2001,
pagine: 691 - 697
SICI:
1529-2908(200108)2:8<691:TBPECT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-DEFICIENT MICE; INHIBITS MULTIPLE FORMS; CELL-DEATH; TRANSCRIPTION FACTOR; NEGATIVE SELECTION; CYCLE PROGRESSION; TUMOR-SUPPRESSOR; TRANSGENIC MICE; HMG-BOX; BCL-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Held, W Univ Lausanne, Ludwig Inst Canc Res, 155 Ch Boveresses, CH-1066 Epalinges,Switzerland Univ Lausanne 155 Ch Boveresses Epalinges Switzerland CH-1066 and
Citazione:
V. Ioannidis et al., "The beta-catenin-TCF-I pathway ensures CD4(+)CD8(+) thymocyte survival", NAT IMMUNOL, 2(8), 2001, pp. 691-697

Abstract

The association of trans-actingT cell factors (TCFs) or lymphoid enhancer factor I (LEF-I) with their coactivator beta -catenin mediates transient transcriptional responses to extracellular Wnt signals. We show here that T cell maturation depends on the presence of the beta -catenin-binding domain in TCF-I. This domain is necessary to mediate the survival of immature CD4+CD8+ double-positive (DP) thymocytes. Accelerated spontaneous thymocyte death in the absence of TCF-I correlates with aberrantly low expression of theanti-apoptotic protein Bcl-x(L). Increasing anti-apoptotic effectors in thymocytes by the use of a Bcl-2 transgene rescued TCF-I-deficient DP thymocytes from apoptosis. Thus, TCF-I, upon association with beta -catenin, transiently ensures the survival of immature T cells, which enables them to generate and edit T cell receptor (TCR) alpha chains and attempt TCR-mediated positive selection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:44:03