Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product
Autore:
Latour, S; Gish, G; Helgason, CD; Humphries, RK; Pawson, T; Veillette, A;
Indirizzi:
Inst Rech Clin Montreal, Mol Oncol Lab, Montreal, PQ H2W 1R7, Canada Inst Rech Clin Montreal Montreal PQ Canada H2W 1R7 al, PQ H2W 1R7, Canada McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 chem, Montreal, PQ H3G 1Y6, Canada McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 Med, Montreal, PQ H3G 1Y6, Canada McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3G 1Y6, Canada McGillUniv Montreal PQ Canada H3G 1Y6 unol, Montreal, PQ H3G 1Y6, Canada Hop Necker Enfants Malad, Unite INSERM U429, Paris, France Hop Necker Enfants Malad Paris France Unite INSERM U429, Paris, France Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Program Mol Biol & Canc, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Canc, Toronto, ON M5G 1X5, Canada British Columbia Canc Res Ctr, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada British Columbia Canc Res Ctr Vancouver BC Canada V5Z 1L3 V5Z 1L3, Canada
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 8, volume: 2, anno: 2001,
pagine: 681 - 690
SICI:
1529-2908(200108)2:8<681:ROSSTB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE PROTEIN-KINASE; ACTIVATION MOLECULE SLAM; SH2 DOMAIN; NEGATIVE REGULATION; CELL-PROLIFERATION; DOCKING PROTEIN; ENCODING GENE; T-CELLS; RECEPTOR; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Veillette, A Inst Rech Clin Montreal, Mol Oncol Lab, 110 Pine Ave W, Montreal, PQ H2W 1R7, Canada Inst Rech Clin Montreal 110 Pine Ave W Montreal PQ Canada H2W 1R7
Citazione:
S. Latour et al., "Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product", NAT IMMUNOL, 2(8), 2001, pp. 681-690

Abstract

Signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) is a short intracellular molecule that is mutated in humans with X-linked lymphoproliferative (XLP) disease. Although the exact role and mechanism of action of SAP are not known, it has the capacity to interact with the cytoplasmic region of SLAM and other related immune cell receptors. As SAP is composed almost exclusively of a Src homology 2 (SH2) domain, it has been proposed that it functions as a natural blocker of SH2 domain-mediated interactions. We report here that the SLAM receptor is capable of triggering a protein tyrosine phosphorylation signal in T cells via a mechanism that is strictly dependent on SAP expression. This signal involves the SH2 domain-containing inositol phosphatase (SHIP);the adaptor molecules Dok2, Dok1 and Shc;and Ras GTPase-activating protein RasGAP. SAP is essential for this pathwaybecause it facilitates the selective recruitment and activation of the Src-related protein tyrosine kinase FynT. We also show that signaling via the SLAM-SAP pathway in an established T cell line can alter the profile of cytokine production during T cell activation. These findings identify a mechanism by which a putative adaptor molecule is required for receptor-mediated signaling events in the immune system. They also provide insights into the pathophysiology of a severe human lymphoproliferative disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:07:46