Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of natural and immune IgM antibodies in immune responses
Autore:
Boes, M;
Indirizzi:
Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA
Titolo Testata:
MOLECULAR IMMUNOLOGY
fascicolo: 18, volume: 37, anno: 2000,
pagine: 1141 - 1149
SICI:
0161-5890(200012)37:18<1141:RONAII>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICULAR DENDRITIC CELLS; SYSTEMIC LUPUS-ERYTHEMATOSUS; T-DEPENDENT ANTIGEN; LY-1 B-CELLS; AUTOIMMUNE-DISEASE; TRANSGENIC MICE; COMPLEMENT RECEPTOR-1; MURINE ANTIBODIES; IMMUNOGLOBULIN-M; INNATE IMMUNITY;
Keywords:
autoimmunity; bacterial infection; complement; immune response; immunoglobulin M; viral infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Boes, M Harvard Univ, Sch Med, Dept Pathol, Bldg D2,200 Longwood Ave, Boston, MA 02115 USA Harvard Univ Bldg D2,200 Longwood Ave Boston MA USA 02115 2115 USA
Citazione:
M. Boes, "Role of natural and immune IgM antibodies in immune responses", MOL IMMUNOL, 37(18), 2000, pp. 1141-1149

Abstract

IgM antibodies constitute the major component of the natural antibodies and is also the first class of antibodies produced during a primary antibody response. The IgM-type antibodies differ from other classes of antibodies in that they are predominantly produced by B1 cells, in the absence of apparent stimulation by specific antigens. In addition, IgM antibodies are mostly encoded by germline V gene segments and have low affinities but broad specificites to both foreign and self structures. New developments regarding the function of both immune IgM antibodies and natural IgM antibodies will be examined here. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 06:58:09