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Titolo:
Age-dependent effects of secreted Semaphorins 3A, 3F, and 3E on developinghippocampal axons: In vitro effects and phenotype of Semaphorin 3A (-/-) mice
Autore:
Pozas, E; Pascual, M; Ba-Charvet, KTN; Guijarro, P; Sotelo, C; Chedotal, A; Del Rio, JA; Soriano, E;
Indirizzi:
Univ Barcelona, Dept Cell Biol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 ll Biol, E-08028 Barcelona, Spain Univ Barcelona, CERN, Ctr Res Neurosci, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 eurosci, E-08028 Barcelona, Spain Hop La Pitie Salpetriere, INSERM U106, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 106, F-75013 Paris, France
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 1, volume: 18, anno: 2001,
pagine: 26 - 43
SICI:
1044-7431(200107)18:1<26:AEOSS3>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH CONE COLLAPSE; POSTNATAL MURINE HIPPOCAMPUS; III COLLAPSIN-1; NERVOUS-SYSTEM; MESSENGER-RNA; NEUROPILIN INTERACTIONS; FIBER PROJECTIONS; NEURITE OUTGROWTH; SENSORY AFFERENTS; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Soriano, E Univ Barcelona, Dept Cell Biol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 08028 Barcelona, Spain
Citazione:
E. Pozas et al., "Age-dependent effects of secreted Semaphorins 3A, 3F, and 3E on developinghippocampal axons: In vitro effects and phenotype of Semaphorin 3A (-/-) mice", MOL CELL NE, 18(1), 2001, pp. 26-43

Abstract

We studied the role of Semaphorins in the formation of hippocampal connections at embryonic and early postnatal stages. We show that the embryonic entorhinal cortex has a repulsive effect on embryonic hippocampal axons that disappears gradually at postnatal stages. Such chemorepulsion is blocked byNeuropilin-1 and -2 blocking antibodies. However, at perinatal stages, theinner layers of the entorhinal cortex attract CA1 axons. At these stages, Sema3A and Sema3F bind commissural and entorhinal axons. Sema3A and Sema3F repel hippocampal axons at E14-P2, but not at E13. A similar spatiotemporalpattern of chemorepulsion is observed for Sema3A on entorhinal axons, in contrast to Sema3F, which repels these axons only at postnatal ages. Sema3E also repels hippocampal axons but exclusively at E14. We show that Sema3A and Sema3F can induce the collapse of hippocampal growth cones and that membrane-bound Sema3A and Sema3F can guide hippocampal axons in the stripe assay. In sema3A (-/-) mice, the entorhinohippocampal projection is largely normal although single axons innervate aberrantly the stratum radiatum and thehilus. Thus, the chemorepulsion evoked by Sema3A, Sema3E, and Sema3F is dynamically regulated in the developing hippocampal formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:16:05