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Titolo:
The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors
Autore:
Kittler, JT; Rostaing, P; Schiavo, G; Fritschy, JM; Olsen, R; Triller, A; Moss, SJ;
Indirizzi:
Univ Coll London, MRC, LMCB, London WC1E 6BT, England Univ Coll London London England WC1E 6BT LMCB, London WC1E 6BT, England Univ Coll London, Dept Pharmacol, London WC1E 6BT, England Univ Coll London London England WC1E 6BT macol, London WC1E 6BT, England Ecole Normale Super, INSERM U497, Lab Biol Cellulaire Synapse, F-75005 Paris, France Ecole Normale Super Paris France F-75005 Synapse, F-75005 Paris, France Imperial Canc Res Fund, Mol Neuropathobiol Lab, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England Univ Zurich, Inst Pharmacol, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 acol, CH-8057 Zurich, Switzerland Univ Calif Los Angeles, Sch Med, Dept Pharmacol, Los Angeles, CA 90095 USAUniv Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 1, volume: 18, anno: 2001,
pagine: 13 - 25
SICI:
1044-7431(200107)18:1<13:TSDOGA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; HIPPOCAMPAL-NEURONS; A RECEPTORS; SYNAPTIC TRANSMISSION; GLYCINE RECEPTOR; SURFACE EXPRESSION; CENTRAL SYNAPSES; AMPA RECEPTORS; KINASE-C; SUBUNIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Moss, SJ Univ Coll London, MRC, LMCB, Gower St, London WC1E 6BT, England Univ Coll London Gower St London England WC1E 6BT E 6BT, England
Citazione:
J.T. Kittler et al., "The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors", MOL CELL NE, 18(1), 2001, pp. 13-25

Abstract

GABA(A) receptors the major sites of fast synaptic inhibition in the brainare composed predominately of alpha, beta, and gamma2 subunits. The receptor gamma2 subunit interacts with a 17-kDa microtubule associated protein GABARAP, but the significance of this interaction remains unknown. Here we demonstrate that GABARAP, which immunoprecipitates with GABAA receptors, is not found at significant levels within inhibitory synapses, but is enriched within the Golgi apparatus and postsynaptic cisternae. We also demonstrate that GABARAP binds directly to N-ethylmaleimide-sensitive factor (NSF), a protein critical for intracellular membrane trafficking events. NSF and GABARAP complexes could be detected in neurons and these two proteins also colocalize within intracellular membrane compartments. Together our observations suggest that GABARAP may play a role in intracellular GABAA receptor transport but not synaptic anchoring, via its ability to interact with NSF. GABARAP may therefore have an important role in the production of GABAergic synapses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:02:50