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Titolo:
The inhibins and ovarian cancer
Autore:
Burger, HG; Fuller, PJ; Chu, S; Mamers, P; Drummond, A; Susil, B; Neva, P; Robertson, DM;
Indirizzi:
Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res Clayton Vic Australia 3168 Vic 3168, Australia Monash Med Ctr, Dept Anat Pathol, Clayton, Vic 3168, Australia Monash Med Ctr Clayton Vic Australia 3168 l, Clayton, Vic 3168, Australia
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 180, anno: 2001,
pagine: 145 - 148
SICI:
0303-7207(20010630)180:1-2<145:TIAOC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRANULOSA-CELL TUMORS; STIMULATING-HORMONE RECEPTOR; ELEVATED SERUM INHIBIN; HUMAN MENSTRUAL-CYCLE; POSTMENOPAUSAL WOMEN; GENE-EXPRESSION; ALPHA-INHIBIN; NEOPLASMS; MUTATIONS; SUBUNITS;
Keywords:
inhibin; alpha-subunit of inhibin; granulosa cell tumour; mucinous tumour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Burger, HG Prince Henrys Inst Med Res, POB 5152, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res POB 5152 Clayton Vic Australia 3168
Citazione:
H.G. Burger et al., "The inhibins and ovarian cancer", MOL C ENDOC, 180(1-2), 2001, pp. 145-148

Abstract

Interest in inhibin as a marker of ovarian malignancy was stimulated by the description of elevated immunoreactive inhibin levels in the sera of patients with granulosa cell tumours. Several groups have confirmed the value of serum inhibin in the diagnosis and follow-up of patients with this uncommon malignancy. Immunoreactive inhibin levels are also frequently elevated in patients with mucinous cystadenocarcinoma and less frequently in other forms of ovarian tumour. Assay of sera using the specific dimeric inhibin assays has shown that ovarian tumours are able to secrete dimeric inhibin particularly inhibin B. The less specific oc-subunit directed assays. however. most frequently show elevated concentrations. Used in combination with CA125 as a dual tumour marker, it appears in principle that inhibin can be a useful diagnostic agent. Immunohistochemistry for the inhibin subunits has been reported with increasing frequency as a helpful method to assess suspected ovarian stromal cell tumours. Its diagnostic accuracy for other types ofovarian adenocarcinoma appears less reliable. Expression of the inhibin subunit mRNAs has been demonstrated in a variety of ovarian malignancies. Theobservation that inhibin levels are elevated in ovarian cancer has stimulated studies of their relevance to the molecular pathogenesis of these malignancies. Findings to date have been largely negative with no evidence for activating mutations of the FSH receptor or of the post-receptor signalling pathway proteins. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:27:11