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Titolo:
Antagonism of activin by inhibin and inhibin receptors: a functional role for betaglycan-glycan
Autore:
Gray, PC; Bilezikjian, LM; Vale, W;
Indirizzi:
Salk Inst Biol Studies, Clayton Fdn Labs Peptide Biol, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Biol, La Jolla, CA 92037 USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 180, anno: 2001,
pagine: 47 - 53
SICI:
0303-7207(20010630)180:1-2<47:AOABIA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; FOLLICLE-STIMULATING-HORMONE; MESSENGER-RIBONUCLEIC-ACID; ANTERIOR-PITUITARY-CELLS; HUMAN ENDOTHELIAL-CELLS; FSH-RELEASING PROTEIN; SITU LIGAND-BINDING; III RECEPTOR; ADRENOCORTICOTROPIN SECRETION; ERYTHROID-DIFFERENTIATION;
Keywords:
activin; inhibin; follistatin; betaglycan; receptor; (pituitary, gonadotrope);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Vale, W Salk Inst Biol Studies, Clayton Fdn Labs Peptide Biol, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies 10010 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
P.C. Gray et al., "Antagonism of activin by inhibin and inhibin receptors: a functional role for betaglycan-glycan", MOL C ENDOC, 180(1-2), 2001, pp. 47-53

Abstract

Activin and inhibin research has provided important insight into reproductive physiology as well as many areas involving regulation of cell growth, differentiation and function. Progress in understanding the roles of these hormones in various cell and tissue types has been complimented by novel discoveries at the molecular level that have shed light on ligand/receptor interactions. signaling mechanisms and regulation. While the receptors and signaling pathway for activin are now well characterized. the molecular basis for inhibin action has remained relatively unclear. Here we summarize recent advances in understanding inhibin's mode of action focusing on our recentidentification of betaglycan-glycan as an inhibin co-receptor capable of mediating inhibin action. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:40:13