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Titolo:
Morphologic responses of endothelium to shear stress: Reorganization of the adherens junction
Autore:
Langille, BL;
Indirizzi:
Univ Hlth Network, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada Univ HlthNetwork Toronto ON Canada M5G 2C4 , Toronto, ON M5G 2C4, Canada Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto Toronto ON Canada Lab Med & Pathobiol, Toronto, ON, Canada
Titolo Testata:
MICROCIRCULATION
fascicolo: 3, volume: 8, anno: 2001,
pagine: 195 - 206
SICI:
1073-9688(200106)8:3<195:MROETS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL ADHESION; ACTIN CYTOSKELETAL DYNAMICS; SIGNAL-REGULATED KINASE; BETA-CATENIN; TYROSINE PHOSPHORYLATION; SMALL GTPASES; G-PROTEINS; V-SRC; COFILIN PHOSPHORYLATION; TEMPORAL GRADIENT;
Keywords:
adherens junction; cadherin; catenin; endothelium; F-actin; G-proteins; integrins; shear stress;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
117
Recensione:
Indirizzi per estratti:
Indirizzo: Langille, BL Univ Hlth Network, Toronto Gen Hosp, 200 Elizabeth St,CCRW 1-836, Toronto,ON M5G 2C4, Canada Univ Hlth Network 200 Elizabeth St,CCRW 1-836 Toronto ON Canada M5G 2C4
Citazione:
B.L. Langille, "Morphologic responses of endothelium to shear stress: Reorganization of the adherens junction", MICROCIRCUL, 8(3), 2001, pp. 195-206

Abstract

Shear stresses induce marked morphologic responses from endothelium which include alterations to cell shape and orientation and changes to cytoskeletal organization. These morphologic changes necessitate remodeling of cell-cell adhesion complexes that are important to control of endothelial cell physiology. Reorganization of endothelial adherens junctions has been characterized, and there are some data that pertain to the signaling pathways thatregulate this reorganization. Shear-induced activation of Src, mitogen-activated protein (MAP) kinase (ERK1/2 and p38), and PI 3'-kinase, pathways are important candidate pathways, and there is evidence for a role for the Rho GTPases. Very little is known concerning shear-dependence of other junctional complexes, but available data indicates a high degree of shear sensitivity. Given the continuous changes in hemodynamics which occur physiologically in vivo, sensitivity of endothelial cell-cell adhesion complexes to shear will likely prove important to vascular pathophysiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:32:20