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Titolo:
Pores in the sieve and channels in the wall: Control of paracellular permeability by junctional proteins in endothelial cells
Autore:
Bazzoni, G; Dejana, E;
Indirizzi:
Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy I-20157 I-20157 Milan, Italy Fdn Italiana Ric Canc, Inst Mol Oncol, Milan, Italy Fdn Italiana Ric CancMilan Italy ic Canc, Inst Mol Oncol, Milan, Italy Univ Insubria, Fac Med & Chirurg, Dipartimento Sci Clin & Biol, Varese, Italy Univ Insubria Varese Italy Dipartimento Sci Clin & Biol, Varese, Italy
Titolo Testata:
MICROCIRCULATION
fascicolo: 3, volume: 8, anno: 2001,
pagine: 143 - 152
SICI:
1073-9688(200106)8:3<143:PITSAC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULE JAM; TIGHT JUNCTION; IMMUNOGLOBULIN SUPERFAMILY; TYROSINE PHOSPHORYLATION; P120 CATENIN; PLASMALEMMAL VESICLES; ADHERENS JUNCTIONS; CADHERIN COMPLEXES; BETA-CATENIN; TNF-ALPHA;
Keywords:
endothelial cells; junctional adhesion molecule; junctions; permeability; VE-cadherin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Dejana, E Mario Negri Inst Pharmacol Res, Via Eritrea 62, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Via Eritrea 62 Milan Italy I-20157
Citazione:
G. Bazzoni e E. Dejana, "Pores in the sieve and channels in the wall: Control of paracellular permeability by junctional proteins in endothelial cells", MICROCIRCUL, 8(3), 2001, pp. 143-152

Abstract

Exchange of solutes and ions between the luminal and abluminal compartments of the circulation is critically dependent on the barrier properties of the vascular endothelium. Transport of solutes and fluids occurs along the transcellular and paracellular pathways that are mediated by intracellular vesicles and intercellular junctions, respectively. Although the ability, ofendothelial cells to dynamically regulate permeability has long been recognized, the precise mechanism and the signaling pathways involved have not been fully elucidated. Finally, current definition of the complex molecular composition of intercellular junctions is expected to explain the difference in permeability between diverse segments of the circulation and possibly to highlight the existence of specific junctional channels. The properties of junctional adhesion molecule-1 (JAM-1) and vascular endothelial cadherin(VE-cadherin), two transmembrane components of inter-endothelial junctions, are described in detail.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:16:17