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Titolo:
Effect of the mouse Nramp1 genotype on the expression of IFN-gamma gene inearly response to Salmonella infection
Autore:
Lalmanach, AC; Montagne, A; Menanteau, P; Lantier, F;
Indirizzi:
INRA, Ctr Rech Tours, Pathol Infect & Immunol Lab, F-37380 Nouzilly, France INRA Nouzilly France F-37380 ect & Immunol Lab, F-37380 Nouzilly, France
Titolo Testata:
MICROBES AND INFECTION
fascicolo: 8, volume: 3, anno: 2001,
pagine: 639 - 644
SICI:
1286-4579(200107)3:8<639:EOTMNG>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; TYPHIMURIUM INFECTION; INTERFERON-GAMMA; IMMUNE-RESPONSE; DENDRITIC CELLS; CYTOKINE EXPRESSION; MURINE SPLENOCYTES; HOST-RESISTANCE; FACTOR-ALPHA;
Keywords:
interferon type II; immunity, natural; Salmonella infections, animal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lalmanach, AC INRA, Ctr Rech Tours, Pathol Infect & Immunol Lab, F-37380 Nouzilly, France INRA Nouzilly France F-37380 Lab, F-37380 Nouzilly, France
Citazione:
A.C. Lalmanach et al., "Effect of the mouse Nramp1 genotype on the expression of IFN-gamma gene inearly response to Salmonella infection", MICROBES IN, 3(8), 2001, pp. 639-644

Abstract

The early interferon-gamma (IFN-gamma) response after Salmonella infectionwas compared in resistant and susceptible congenic mice strains differing by the allele of Nramp1. IFN-gamma gene expression in vivo was studied by quantitative reverse transcript ion-PCR performed from the spleen of mice challenged by Salmonella either in multiplication or in resting phase. The spleen colonisation by Salmonella in vivo was investigated and was shown to be identical in a genetically defined host, whatever the initial phase of the bacteria. However, the bacterial toad of the spleen was significantly reduced in Nramp1(r) (resistant) mice compared to Nramp1(s) (susceptible) mice. The background level of IFN-gamma mRNA was higher in the spleen of resistant mice than in the susceptible mice, before infection. Interestingly, theearly upregulation of IFN-gamma gene transcription, which was observed after infection with Salmoella was reproducibly delayed in susceptible mice compared to resistant mice. Finally, the kinetics of the host IFN-gamma response seems to be Nramp1 dependent. Resistant mice present the advantage of being more prompt to express this anti-infectious cytokine gene than susceptible mice in response to Salmonella infection. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:30:43