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Titolo:
A single-cell model to study changes in neuronal fractal dimension
Autore:
Borodinsky, LN; Fiszman, ML;
Indirizzi:
Consejo Nacl Invest Cient & Tecn, Inst Invest Farmacol, ININFA, RA-1113 Buenos Aires, DF, Argentina Consejo Nacl Invest Cient & Tecn Buenos Aires DFArgentina RA-1113 entina
Titolo Testata:
METHODS
fascicolo: 4, volume: 24, anno: 2001,
pagine: 341 - 345
SICI:
1046-2023(200108)24:4<341:ASMTSC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE CELLS; POTASSIUM CONCENTRATION; DEPOLARIZATION; CALCIUM; GROWTH; DIFFERENTIATION; SURVIVAL; CULTURE;
Keywords:
neuronal complexity; cerebellar granule cells; fractal dimension; neural activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Fiszman, ML Consejo Nacl Invest Cient & Tecn, Inst Invest Farmacol, ININFA, Junin 956 5 Piso, RA-1113 Buenos Aires, DF, Argentina Consejo Nacl InvestCient & Tecn Junin 956 5 Piso Buenos Aires DF Argentina RA-1113
Citazione:
L.N. Borodinsky e M.L. Fiszman, "A single-cell model to study changes in neuronal fractal dimension", METHODS, 24(4), 2001, pp. 341-345

Abstract

Many methods have been developed to quantify neuronal morphology: measurement of neurite length, neurite number, etc. However, none of these approaches provides a comprehensive view of the complexity of neuronal morphology. In this work we have analyzed the evaluation of fractal dimension (D) as a tool to represent and quantify changes in complexity of the dendritic arbor, in in vitro cultures grown under low-density conditions. Neurons grown inisolation developed a bipolar morphology corresponding to a fractal dimension close to the unit. The analysis showed that neuronal complexity increased when cells were incubated with a depolarizing potassium concentration and there was a correlation with an increase in fractal dimension (D-5 (mM) (KCl) = 1.08 +/- 0.01, D-25 (mM) (KCl) = 1.25 +/- 0.01). We conclude that fractal dimension is a suitable parameter to quantify changes in neuronal morphological complexity. (C) 2001 Academic Press.

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Documento generato il 24/01/20 alle ore 15:30:06