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Titolo:
Decreased activities of lipoprotein lipase and hepatic triglyceride lipasein patients with gout
Autore:
Tsutsumi, Z; Yamamoto, T; Moriwaki, Y; Takahashi, S; Hada, T;
Indirizzi:
Hyogo Med Univ, Dept Internal Med 3, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 8, volume: 50, anno: 2001,
pagine: 952 - 954
SICI:
0026-0495(200108)50:8<952:DAOLLA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL INTAKE; HYPERTRIGLYCERIDEMIA; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Moriwaki, Y Hyogo Med Univ, Dept Internal Med 3, Mukogawa Cho 1-1, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ Mukogawa Cho 1-1 Nishinomiya Hyogo Japan 6638501
Citazione:
Z. Tsutsumi et al., "Decreased activities of lipoprotein lipase and hepatic triglyceride lipasein patients with gout", METABOLISM, 50(8), 2001, pp. 952-954

Abstract

Postheparin plasma lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) activities were measured in 30 male primary gout patients as well as in control subjects. The activities of these lipolytic enzymes were significantly decreased in the patients as compared with the controls (gout v control; LPL,5.4 +/-0.4 v 7.9 +/-0.9 U; HTGL, 14.6 +/-2.0 v 17.9 +/-3.4 U) when matched with serum triglyceride concentration. Further, LPL activity was negatively correlated with serum- and very-low-density lipoprotein (VLDL)-triglyceride in gout patients, while that of HTGL was negatively correlated with low-density lipoprotein (LDL)-triglyceride in both gout patients andcontrol subjects. These results suggest that decreased activities of LPL and HTGL may contribute, in part, to the increased concentrations of serum-,VLDL-, and LDL-triglyceride seen in gout patients, leading to a higher risk for coronary atherosclerotic diseases in gout. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:43:34