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Titolo:
Chronic hepatitis C and superimposed nonalcoholic fatty liver disease
Autore:
Ong, JP; Younossi, ZM; Speer, C; Olano, A; Gramlich, T; Boparai, N;
Indirizzi:
Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Falls Church, VA 22042 USA Inova Fairfax Hosp Falls Church VA USA 22042 , Falls Church, VA 22042 USA Cleveland Clin Fdn, Dept Gastroenterol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 nterol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA
Titolo Testata:
LIVER
fascicolo: 4, volume: 21, anno: 2001,
pagine: 266 - 271
SICI:
0106-9543(200108)21:4<266:CHCASN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-HISTORY; INFECTION; STEATOSIS; SEVERITY; FIBROSIS;
Keywords:
fibrosis; HCV; NAFL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Younossi, ZM Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, 3300 Gallows Rd,Falls Church, VA 22042 USA Inova Fairfax Hosp 3300 Gallows Rd Falls ChurchVA USA 22042
Citazione:
J.P. Ong et al., "Chronic hepatitis C and superimposed nonalcoholic fatty liver disease", LIVER, 21(4), 2001, pp. 266-271

Abstract

Background/Aims: Hepatitis C and nonalcoholic fatty liver disease (NAFL) are the two most common forms of liver disease in the United States. Recently, obesity and its associated risk factors have been suggested to enhance HCV-related fibrosis. The aim of this study was to assess the impact of hepatic steatosis, steatohepatitis, and its associated risk factors on HCV-related fibrosis. Methods: Patients with untreated, biopsy-proven, chronic hepatitis C (6/97-3/99) were included. Clinical and demographic data at the time of liver biopsy were obtained from chart review and verified by telephonesurvey. One hepatopathologist reviewed all pathologic specimens, using themodified histological activity index score and the Ishak staging for fibrosis and a NAFL pathologic, protocol. Results: One hundred and seventy patients with hepatitis C were included [age: 48.7 +/- 9.33 (years), body mass index (BMI): 28.1 +/- 5.7 (kg/m(2)) and type 2 diabetes mellitus (DM): 14%]. Of these, 77 (45.3%) had no or mild fibrosis and 93 (54.7%) had advanced fibrosis. Hepatic steatosis, was seen in 90 (52.9%) patients. The grade of steatosis was associated with markers of obesity only. Age (p=0.002), type 2DM (p=0.04), and superimposed steatohepatitis (p=0.047) were independentlyassociated with advanced fibrosis. Superimposed nonalcoholic steatohepatitis (NASH) was seen in 17 (10%) patients. Patients with superimposed NASH were mostly obese (76.5%), mates (62%) with 16% having type 2 diabetes and a BMI 33.8+/-7.12. Conclusion: In patients with chronic hepatitis C, type 2 DM and superimposed steatohepatitis are independently associated with advanced fibrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:22:12