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Titolo:
Over-expression of the functional interleukin-11 alpha receptor in the development of B-cell chronic lymphocytic leukemia
Autore:
Tsimanis, A; Shvidel, L; Klepfish, A; Shtalrid, M; Kalinkovich, A; Berrebi, A;
Indirizzi:
Kaplan Med Ctr, Dept Hematol, IL-76100 Rehovot, Israel Kaplan Med Ctr Rehovot Israel IL-76100 Hematol, IL-76100 Rehovot, Israel
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 1-2, volume: 42, anno: 2001,
pagine: 195 - 205
SICI:
1042-8194(200106)42:1-2<195:OOTFIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; REGULATES BCL-2 EXPRESSION; MESSENGER-RNA EXPRESSION; NECROSIS-FACTOR-ALPHA; MOLECULAR-CLONING; HEMATOPOIETIC CYTOKINE; GENE-EXPRESSION; CLL CELLS; IN-VITRO; DEATH;
Keywords:
B-chronic lymphocytic leukemia; expression; interleukin-11; interleukin-11 alpha receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Tsimanis, A Kaplan Med Ctr, Dept Hematol, POB 1, IL-76100 Rehovot, Israel Kaplan Med Ctr POB 1 Rehovot Israel IL-76100 Rehovot, Israel
Citazione:
A. Tsimanis et al., "Over-expression of the functional interleukin-11 alpha receptor in the development of B-cell chronic lymphocytic leukemia", LEUK LYMPH, 42(1-2), 2001, pp. 195-205

Abstract

Several cytokines have been found to play a role in the pathogenesis of B-CLL. In the present study using reverse-transcriptase polymerase chain reaction (RT-PCR), FACS analysis and immunofluorescence we have shown the constitutive expression of IL-11 and IL-11R alpha in B-chronic lymphocytic leukemia (B-CLL). The expression level of IL-11R alpha in B-CLL cells is much higher than in PBL of normal donors. Recombinant human IL-11 (rhIL-11) activates B-CLL cells, leading to morphologic alterations of the cells and increase in cell number and size. Short-term cultivation in the presence of rhIL-11 did not lead to quantitative changes in the ratio of the living vs apoptotic and dead cells. However, in contrast to rhIL-6, pretreatment with rhIL-11, did not cause B-CLL cells to be resistant to the action of dexamethasone. These data suggest an essential role for the IL-11/IL11R alpha system in the pathogenesis of the malignant B-CLL cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:41:27