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Titolo:
Interactions between P-glycoprotein and drugs used in the supportive care of acute myeloid leukemia patients
Autore:
Mollgard, L; Hellberg, E; Smolowicz, A; Paul, C; Tidefelt, U;
Indirizzi:
Huddinge Univ Hosp, Dept Hematol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 tol, S-14186 Huddinge, Sweden
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 1-2, volume: 42, anno: 2001,
pagine: 177 - 185
SICI:
1042-8194(200106)42:1-2<177:IBPADU>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIDRUG-RESISTANT CELLS; SOUTHWEST-ONCOLOGY-GROUP; MDR1 GENE-EXPRESSION; CLINICAL-SIGNIFICANCE; CYCLOSPORINE-A; DAUNORUBICIN; OVEREXPRESSION; ACCUMULATION; VINBLASTINE; VINCRISTINE;
Keywords:
antibiotics; P-glycoprotein; acute myeloid leukemia; HL-60 cell line; rhodamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Mollgard, L Huddinge Univ Hosp, Dept Hematol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 Huddinge, Sweden
Citazione:
L. Mollgard et al., "Interactions between P-glycoprotein and drugs used in the supportive care of acute myeloid leukemia patients", LEUK LYMPH, 42(1-2), 2001, pp. 177-185

Abstract

Multidrug resistance due to overexpression of P-glycoprotein (Pgp) leads to reduced intracellular drug accumulation and makes the cells resistant to chemotherapy. In this study we focused on how drugs used in the supportive care of acute myeloid leukemia (AML) patients interfere with Pgp., The effect on intracellular accumulation of the fluorescent dye Rhodamine 123 (Rh 123) was studied in the human promyelocytic leukemia cell line HL-60 and twoanthracycline resistant, Pgp expressing, sublines. Each drug was used at two different concentrations: plasma peak concentration and half the plasma peak concentration. Drugs which increased the Rh 123 uptake by >10% were included in the second part of the study where the cytotoxic effect was tested in combination with daunorubicin. In the Rhodamine assay none of the tested drugs had any significant effect on the Rh 123 efflux in the resistant cell lines. Amphotericin B, cefuroxime, erythromycin and dixyrazin had minoreffects on Rh 123 uptake but showed a significant additive effect to the toxicity of daunorubicin suggesting other mechanisms of action than reversalof Pgp. In conclusion this in vitro model where Rh 123 uptake was studied in an anthracycline resistant leukemia cell line could not demonstrate any significant interactions with Pgp for the tested drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:32:08