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Titolo:
Broad alterations of self-reactive antibody-repertoires of plasma IgM and IgG in B-cell chronic lymphocytic leukemia (B-CLL) and B-CLL related target-restricted autoimmunity
Autore:
Stahl, D; Lacroix-Desmazes, S; Sibrowski, W; Kazatchkine, MD; Kaveri, SV;
Indirizzi:
INSERM, U430, Paris, France INSERM Paris FranceINSERM, U430, Paris, France
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 1-2, volume: 42, anno: 2001,
pagine: 163 - 176
SICI:
1042-8194(200106)42:1-2<163:BAOSAO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL HUMAN SERUM; AUTOREACTIVE REPERTOIRES; AUTOANTIBODY ACTIVITY; HEALTHY-ADULTS; ANTIGENS; IMMUNOGLOBULIN; EXPRESSION; SELECTION; STABILITY; DYNAMICS;
Keywords:
B-CLL; autoimmunity; antibody repertoires; quantitative immunoblotting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Stahl, D Univ Munster, Inst Transfus Med & Transplantat Immunol, Domagkstr11, D-48149 Munster, Germany Univ Munster Domagkstr 11 Munster Germany D-48149 nster, Germany
Citazione:
D. Stahl et al., "Broad alterations of self-reactive antibody-repertoires of plasma IgM and IgG in B-cell chronic lymphocytic leukemia (B-CLL) and B-CLL related target-restricted autoimmunity", LEUK LYMPH, 42(1-2), 2001, pp. 163-176

Abstract

B-cell chronic lymphocytic leukemia (B-CLL) is characterized by a malignant CD5(+) B-cell clone. The leukemic clone commonly expresses IgM antibodiesexhibiting reactivity toward a wide range of self-antigens. However, B-CLLassociated autoimmunity is typically restricted to self-antigens expressedby blood cells, and mediated by IgG autoantibodies of polyclonal origin. In the present study, we addressed the question whether self-reactive antibody repertoires of plasma IgM and IgG are disturbed by monoclonal immunoglobulins of B-CLL patients, and whether antibody repertoires of patients exhibiting B-CLL associated target-restricted autoimmune disease (AID) differ from those of B-CLL patients without AID. We investigated antibody repertoires at a global level, using a technique of quantitative immunoblotting that allows for the quantitative screening of antibody reactivities in complex antibody mixtures toward a large panel of antigens derived from homologous tissue extracts, followed by multiparametric statistical analysis of the data. We demonstrate that self-reactive antibody repertoires of plasma IgM andIgG are broadly altered in patients with B-CLL, that alterations in self-reactive antibody repertoires are not restricted to B-CLL patients exhibiting ADD, and that target-restricted autoimmunity in B-CLL patients is associated with altered antibody repertoires not restricted to the target organ. We conclude that monoclonal alterations of immunoglobulin production in B-CLL are associated with broad defects of self-reactive antibody repertoires. Our observations suggest that the application of therapeutic IVIg preparations might influence B-CLL by restoring normal self-reactive antibody repertoires in plasma.

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Documento generato il 30/03/20 alle ore 13:30:47